Cebpa - CCAAT/enhancer binding protein (C/EBP), alpha Gene

Mus musculus

Also known as Cebp; CBF-A; C/ebpalpha

Gene ID: 12606 | Gene type: protein coding

About Cebpa

Summary

This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. The use of alternative in-frame non-AUG (CUG) and AUG start codons results in several protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the CUG and the first AUG start codons. [provided by RefSeq, Sep 2014]

Cebpa Products(5)

mRNA	Protein	Name
NM_001287514.1	NP_001274443.1	CCAAT/enhancer-binding protein alpha isoform c
NM_001287515.1	NP_001274444.1	CCAAT/enhancer-binding protein alpha isoform d
NM_001287521.1	NP_001274450.1	CCAAT/enhancer-binding protein alpha isoform b
NM_001287523.1	NP_001274452.1	CCAAT/enhancer-binding protein alpha isoform e
NM_007678.3	NP_031704.2	CCAAT/enhancer-binding protein alpha isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	10510303	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	10233885	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	17213233	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	10859308	MGI
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	17290224	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	10233885	MGI
enables chromatin DNA binding	IDA IDA: Inferred from direct assay	25921091	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	22780989	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	12821655	MGI
enables kinase binding	IPI IPI: Inferred from physical interaction	15107404	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10082561	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	11672531	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	18632661	MGI
enables transcription factor binding	IPI IPI: Inferred from physical interaction	17090532	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within Notch signaling pathway	IDA IDA: Inferred from direct assay	25446530	MGI
acts upstream of or within brown fat cell differentiation	IDA IDA: Inferred from direct assay	18492766	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	15073037	MGI
acts upstream of or within cellular response to lithium ion	IDA IDA: Inferred from direct assay	15673614	MGI
acts upstream of or within cellular response to organic cyclic compound	IDA IDA: Inferred from direct assay	12055200	MGI
acts upstream of or within cellular response to tumor necrosis factor	IDA IDA: Inferred from direct assay	1618860	MGI
acts upstream of or within cholesterol metabolic process	IMP IMP: Inferred from mutant phenotype	18974039	MGI
acts upstream of or within embryonic placenta development	IGI IGI: Inferred from genetic interaction	15509779	MGI
involved in energy homeostasis	IDA IDA: Inferred from direct assay	36977414	MGI
acts upstream of or within epithelial cell maturation	IMP IMP: Inferred from mutant phenotype	16467360	MGI
acts upstream of or within fat cell differentiation	IDA IDA: Inferred from direct assay	12037571	MGI
involved in fat cell differentiation	IDA IDA: Inferred from direct assay	11672531	MGI
involved in fat cell differentiation	IMP IMP: Inferred from mutant phenotype	1935900	MGI
involved in glucose homeostasis	IMP IMP: Inferred from mutant phenotype	8798745	MGI
involved in granulocyte differentiation	IDA IDA: Inferred from direct assay	11672531	MGI
involved in granulocyte differentiation	IMP IMP: Inferred from mutant phenotype	15589173	MGI
acts upstream of hematopoietic stem cell proliferation	IMP IMP: Inferred from mutant phenotype	15073037	MGI
acts upstream of or within inner ear development	IDA IDA: Inferred from direct assay	21795542	MGI
involved in lipid homeostasis	IMP IMP: Inferred from mutant phenotype	17290224	MGI
acts upstream of or within liver development	IMP IMP: Inferred from mutant phenotype	17021047	MGI
involved in liver development	IMP IMP: Inferred from mutant phenotype	8798745	MGI
acts upstream of or within lung development	IMP IMP: Inferred from mutant phenotype	16467360	MGI
involved in lung development	IMP IMP: Inferred from mutant phenotype	8798745	MGI
acts upstream of or within macrophage differentiation	IMP IMP: Inferred from mutant phenotype	15073037	MGI
acts upstream of or within mitochondrion organization	IMP IMP: Inferred from mutant phenotype	11940593	MGI
involved in myeloid cell differentiation	IDA IDA: Inferred from direct assay	15664994	MGI
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11672531	MGI
involved in negative regulation of cell cycle	IDA IDA: Inferred from direct assay	15107404	MGI
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	11672531	MGI
acts upstream of or within negative regulation of hematopoietic stem cell proliferation	IMP IMP: Inferred from mutant phenotype	15073037	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10859308	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	17213233	MGI
acts upstream of or within positive regulation of fat cell differentiation	IDA IDA: Inferred from direct assay	10937998	MGI
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	16445384	MGI
involved in positive regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	21131957	MGI
involved in positive regulation of macrophage activation	IMP IMP: Inferred from mutant phenotype	21131957	MGI
acts upstream of or within positive regulation of osteoblast differentiation	IDA IDA: Inferred from direct assay	15175325	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18632661	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10233885	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	10075730	MGI
acts upstream of or within regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	17021047	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18632661	MGI
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17090532	MGI
acts upstream of or within urea cycle	IDA IDA: Inferred from direct assay	17213233	MGI
acts upstream of or within white fat cell differentiation	IMP IMP: Inferred from mutant phenotype	15130516	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in nucleus	IDA IDA: Inferred from direct assay	36977414	MGI
located in nucleus	IDA IDA: Inferred from direct assay	11672531	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	12861022	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

CCAAT/enhancer-binding protein alpha

C/EBP alpha

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-132607A	MTL-CEBPA sodium		94.63%	Phase 2
HY-132607	MTL-CEBPA		95.52%	Phase 2

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-168483	FTO-IN-13		/	Unkown
HY-RS02445	CEBPA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18653	Cebpa Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS25139	Cebpa Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cebpa	NCBI	NCBI:1050

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