2. Gene
  3. Cdh8 - cadherin 8 Gene

Cdh8 - cadherin 8 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as cad8

Gene ID: 12564 | Gene type: protein coding

About Cdh8

Summary

This gene encodes a member of the Cadherin family of calcium-dependent glycoproteins that mediate cell adhesion and regulate many morphogenetic events during development. The encoded preproprotein is further processed to generate a mature protein. Mice lacking the encoded protein exhibit reduced behavioral responses to cold, but not thermal stimuli. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. Multiple distinct genes of the Cadherin family, including this gene, are found on chromosome 8. [provided by RefSeq, Oct 2015]

Cdh8 Products(4)

mRNA Protein Name
NM_001039154.2 NP_001034243.1 cadherin-8 isoform 1 precursor
NM_001285913.1 NP_001272842.1 cadherin-8 isoform 3 precursor
NM_001285914.1 NP_001272843.1 cadherin-8 isoform 4 precursor
NM_007667.3 NP_031693.2 cadherin-8 isoform 2 preproprotein
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
18682221 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
17392463 MGI
involved in regulation of synapse organization IDA
IDA: Inferred from direct assay
25126785 MGI
involved in regulation of synapse organization IMP
IMP: Inferred from mutant phenotype
25126785 MGI
acts upstream of or within response to cold IMP
IMP: Inferred from mutant phenotype
17392463 MGI
acts upstream of or within synaptic transmission, glutamatergic IMP
IMP: Inferred from mutant phenotype
17392463 MGI
Cellular Component GO Annotation Evidence Reference Source
located in axon terminus IDA
IDA: Inferred from direct assay
17392463 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
25158904 MGI
located in synaptic cleft IDA
IDA: Inferred from direct assay
17392463 MGI
is active in synaptic membrane IDA
IDA: Inferred from direct assay
25158904 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cadherin-8

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02341 CDH8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18751 Cdh8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25238 Cdh8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cdh8 NCBI NCBI:1006
Rattus norvegicus Cdh8 NCBI NCBI:84408