Noct - nocturnin Gene

Mus musculus

Also known as Ccr4; Ccrn4l

Gene ID: 12457 | Gene type: protein coding

About Noct

Summary

Enables mRNA binding activity and poly(A)-specific ribonuclease activity. Involved in several processes, including negative regulation of osteoblast differentiation; positive regulation of fat cell differentiation; and regulation of gene expression. Acts upstream of or within P-body assembly; circadian rhythm; and deadenylation-dependent decapping of nuclear-transcribed mRNA. Located in P-body; nucleus; and perinuclear region of cytoplasm. Is expressed in 2-cell stage embryo; central nervous system; and retina. Orthologous to human NOCT (nocturnin). [provided by Alliance of Genome Resources, Apr 2022]

Noct Products(1)

mRNA	Protein	Name
NM_009834.2	NP_033964.1	nocturnin

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables mRNA binding	IDA IDA: Inferred from direct assay	20685873	MGI
enables poly(A)-specific ribonuclease activity	IDA IDA: Inferred from direct assay	17400819	MGI
enables poly(A)-specific ribonuclease activity	IMP IMP: Inferred from mutant phenotype	22073225	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	18625844	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within P-body assembly	IGI IGI: Inferred from genetic interaction	18625844	MGI
involved in circadian regulation of gene expression	IMP IMP: Inferred from mutant phenotype	20685873	MGI
involved in circadian rhythm	IEP IEP: Inferred from expression pattern	20685873	MGI
acts upstream of or within deadenylation-dependent decapping of nuclear-transcribed mRNA	IGI IGI: Inferred from genetic interaction	18625844	MGI
involved in mRNA stabilization	IMP IMP: Inferred from mutant phenotype	22073225	MGI
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	20685873	MGI
involved in negative regulation of osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	20498072	MGI
involved in positive regulation of fat cell differentiation	IMP IMP: Inferred from mutant phenotype	20498072	MGI
involved in regulation of circadian rhythm	IMP IMP: Inferred from mutant phenotype	22073225	MGI
involved in regulation of embryonic development	IMP IMP: Inferred from mutant phenotype	23449310	MGI
involved in response to lipopolysaccharide	IDA IDA: Inferred from direct assay	22073225	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in P-body	IDA IDA: Inferred from direct assay	18625844	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	20498072	MGI
located in nucleus	IDA IDA: Inferred from direct assay	23449310	MGI
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	20498072	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

nocturnin

CCR4 carbon catabolite repression 4-like	CCR4 protein homolog
carbon catabolite repression 4 homolog	carbon catabolite repression 4-like protein
circadian deadenylase NOC

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09402	NOCT Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS22263	Noct Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Noct	NCBI	NCBI:25819

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