Cbx4 - chromobox 4 Gene

Mus musculus

Also known as PC2; MPc2

Gene ID: 12418 | Gene type: protein coding

About Cbx4

Summary

Enables several functions, including SUMO binding activity; SUMO transferase activity; and nucleic acid binding activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II and protein sumoylation. Located in nuclear body. Is expressed in several structures, including adrenal gland; brain; gut; lung; and thymus. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human CBX4 (chromobox 4). [provided by Alliance of Genome Resources, Apr 2022]

Cbx4 Products(1)

mRNA	Protein	Name
NM_007625.2	NP_031651.2	E3 SUMO-protein ligase CBX4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables SUMO binding	IDA IDA: Inferred from direct assay	20176810	MGI
enables SUMO transferase activity	EXP EXP: Inferred from Experiment	17439403	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	17392792	MGI
enables methylated histone binding	IDA IDA: Inferred from direct assay	16537902	MGI
enables phosphoprotein binding	IPI IPI: Inferred from physical interaction	9367786	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9367786	MGI
enables single-stranded RNA binding	IDA IDA: Inferred from direct assay	16537902	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	20417598	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9367786	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	20417598	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17392792	MGI
acts upstream of or within protein sumoylation	IMP IMP: Inferred from mutant phenotype	20176810	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nuclear body	IDA IDA: Inferred from direct assay	20417598	MGI
located in nucleus	IDA IDA: Inferred from direct assay	16537902	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

E3 SUMO-protein ligase CBX4

E3 SUMO-protein transferase CBX4	chromobox homolog 4
chromobox protein homolog 4	polycomb 2 homolog

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02011	CBX4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20702	Cbx4 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cbx4	NCBI	NCBI:8535

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