2. Gene
  3. Cbl - Casitas B-lineage lymphoma Gene

Cbl - Casitas B-lineage lymphoma Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as cbl; Cbl-2; c-Cbl; 4732447J05Rik

Gene ID: 12402 | Gene type: protein coding

About Cbl

Summary

Enables SH3 domain binding activity and Ephrin Receptor binding activity. Involved in regulation of platelet-derived growth factor receptor-alpha signaling pathway. Acts upstream of or within regulation of Rap protein signal transduction. Located in Golgi apparatus and cilium. Part of flotillin complex. Is expressed in male reproductive system and urinary system. Human ortholog(s) of this gene implicated in acute myeloid leukemia; juvenile myelomonocytic leukemia; lung non-small cell carcinoma; and myeloid neoplasm. Orthologous to human CBL (Cbl proto-oncogene). [provided by Alliance of Genome Resources, Apr 2022]

Cbl Products(1)

mRNA Protein Name
NM_007619.2 NP_031645.2 E3 ubiquitin-protein ligase CBL
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables SH3 domain binding IPI
IPI: Inferred from physical interaction
9447983 MGI
enables ephrin receptor binding IPI
IPI: Inferred from physical interaction
18034775 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
7657591 MGI
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
15383614 MGI
enables ubiquitin protein ligase activity IGI
IGI: Inferred from genetic interaction
11823423 MGI
enables ubiquitin protein ligase activity IMP
IMP: Inferred from mutant phenotype
12754251 MGI
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of epidermal growth factor receptor signaling pathway IDA
IDA: Inferred from direct assay
23457600 MGI
involved in negative regulation of epidermal growth factor receptor signaling pathway IGI
IGI: Inferred from genetic interaction
11823423 MGI
involved in negative regulation of epidermal growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
12754251 MGI
involved in protein ubiquitination IDA
IDA: Inferred from direct assay
23457600 MGI
acts upstream of or within regulation of Rap protein signal transduction IMP
IMP: Inferred from mutant phenotype
12671687 MGI
involved in regulation of platelet-derived growth factor receptor-alpha signaling pathway IMP
IMP: Inferred from mutant phenotype
29237719 MGI
involved in ubiquitin-dependent endocytosis IMP
IMP: Inferred from mutant phenotype
15383614 MGI
involved in ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
23457600 MGI
Cellular Component GO Annotation Evidence Reference Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
29237719 MGI
located in cilium IDA
IDA: Inferred from direct assay
29237719 MGI
part of flotillin complex IDA
IDA: Inferred from direct assay
11001060 MGI
is active in plasma membrane IDA
IDA: Inferred from direct assay
15383614 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase CBL

RING-type E3 ubiquitin transferase CBL

casitas B-lineage lymphoma proto-oncogene

proto-oncogene c-CBL

signal transduction protein CBL

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-18935A CBL0137 hydrochloride 99.72% Phase 2
HY-18935 CBL0137 99.68% Phase 2
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99636 Gavilimomab / Phase 3
Pre-clinical Phase
Bioactive Molecules (33)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-141432 NX-1607 Inhibitor 99.87% Unkown
HY-136339 Cbl-b-IN-1 Inhibitor 99.66% Unkown
HY-141431 Cbl-b-IN-2 Inhibitor / Unkown
HY-155120 Cbl-b-IN-5 Inhibitor 99.61% Unkown
HY-W176629 Hydrocotarnine Inhibitor 99.59% Unkown
HY-E70079 Cystathionine β-lyase, Recombinant Microorganisms / Unkown
HY-156768 Cbl-b-IN-12 Inhibitor / Unkown
HY-155477 Cbl-b-IN-15 Inhibitor / Unkown
HY-156762 Cbl-b-IN-6 Inhibitor / Unkown
HY-156763 Cbl-b-IN-7 Inhibitor / Unkown
HY-156764 Cbl-b-IN-8 Inhibitor / Unkown
HY-156765 Cbl-b-IN-9 Inhibitor / Unkown
HY-156766 Cbl-b-IN-10 Inhibitor / Unkown
HY-156767 Cbl-b-IN-11 Inhibitor / Unkown
HY-156769 Cbl-b-IN-13 Inhibitor / Unkown
HY-158171 Cbl-b-IN-17 Inhibitor / Unkown
HY-158172 Cbl-b-IN-18 Inhibitor / Unkown
HY-158173 Cbl-b-IN-19 Inhibitor / Unkown
HY-158174 Cbl-b-IN-20 Inhibitor / Unkown
HY-159608 PROTAC Cbl-b-IN-1 / Unkown
HY-159615 Cbl-b-IN-21 / Unkown
HY-159617 Cbz-Pip-2C-Pip-C-Pip / Unkown
HY-159618 (3S)Lenalidomide-5-Pip-C-Pip-2C-Pip / Unkown
HY-161977 Cbl-b-IN-26 Inhibitor / Unkown
HY-163194 Cbl-b-IN-16 Inhibitor / Unkown
HY-169005 Cbl-b-IN-27 Inhibitor / Unkown
HY-173311 Cbl-b-IN-28 / Unkown
HY-P10412 A11 Inhibitor / Unkown
HY-RS01996 CBL Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-W797329 (3S)Lenalidomide-5-Br / Unkown
HY-141432G NX-1607 (GMP) Inhibitor / Unkown
HY-RS17014 Cbl Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23457 Cbl Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cbl NCBI NCBI:867
Rattus norvegicus Cbl NCBI NCBI:500985