1. Gene
  2. Cav2 - caveolin 2 Gene

Cav2 - caveolin 2 Gene

Mus musculus
Gene ID: 12390 | Gene type: protein coding

About Cav2

Summary

This gene belongs to the caveolin family whose members encode the major protein components of caveolae, which are invaginations of plasma membrane. This gene is located adjacent to caveolin-1 and the proteins coexpressed by the two genes localize together in caveolae, where they form hetero-oligomers. The encoded protein may be involved in diverse cellular functions including proliferation, differentiation, endocytosis and trafficking. Alternative splicing of this gene results in transcript variants encoding different isoforms. [provided by RefSeq, Apr 2013]

Cav2 Products(2)

mRNA Protein Name
NM_001277756.1 NP_001264685.1 caveolin-2 isoform 2
NM_016900.4 NP_058596.1 caveolin-2 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables molecular adaptor activity IDA
IDA: Inferred from direct assay
12091389 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17715130 MGI
enables protein heterodimerization activity IPI
IPI: Inferred from physical interaction
9361015 MGI
enables protein kinase binding IDA
IDA: Inferred from direct assay
12091389 MGI
enables protein kinase binding IPI
IPI: Inferred from physical interaction
12091389 MGI
enables protein-macromolecule adaptor activity IDA
IDA: Inferred from direct assay
12091389 MGI
enables scaffold protein binding IPI
IPI: Inferred from physical interaction
12091389 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within basement membrane organization IMP
IMP: Inferred from mutant phenotype
11884617 MGI
acts upstream of cell population proliferation IMP
IMP: Inferred from mutant phenotype
17200204 MGI
acts upstream of or within endoplasmic reticulum organization IMP
IMP: Inferred from mutant phenotype
17200204 MGI
acts upstream of endothelial cell proliferation IGI
IGI: Inferred from genetic interaction
21832243 MGI
acts upstream of endothelial cell proliferation IMP
IMP: Inferred from mutant phenotype
11884617 MGI
acts upstream of or within mitochondrion organization IMP
IMP: Inferred from mutant phenotype
17200204 MGI
acts upstream of or within negative regulation of endothelial cell proliferation IMP
IMP: Inferred from mutant phenotype
11884617 MGI
acts upstream of or within negative regulation of skeletal muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
17200204 MGI
acts upstream of or within negative regulation of transforming growth factor beta receptor signaling pathway IGI
IGI: Inferred from genetic interaction
21832243 MGI
acts upstream of or within positive regulation of endothelial cell proliferation IGI
IGI: Inferred from genetic interaction
21832243 MGI
acts upstream of skeletal muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
17200204 MGI
acts upstream of or within skeletal muscle fiber development IMP
IMP: Inferred from mutant phenotype
17200204 MGI
acts upstream of transforming growth factor beta receptor signaling pathway IGI
IGI: Inferred from genetic interaction
21832243 MGI
Cellular Component GO Annotation Evidence Reference Source
located in acrosomal membrane IDA
IDA: Inferred from direct assay
19144954 MGI
located in caveola IDA
IDA: Inferred from direct assay
11884617 MGI
part of caveolar macromolecular signaling complex IDA
IDA: Inferred from direct assay
11884617 MGI
colocalizes with focal adhesion IDA
IDA: Inferred from direct assay
12091389 MGI
located in membrane IDA
IDA: Inferred from direct assay
11316799 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
11884617 MGI
part of protein-containing complex IDA
IDA: Inferred from direct assay
12091389 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

caveolin-2

Orthologs Information

Species Symbol Source ID
Homo sapiens Cav2 NCBI NCBI:858