Cask - calcium/calmodulin-dependent serine protein kinase (MAGUK family) Gene

Mus musculus

Also known as LIN-2; Pals3; DXPri1; DXRib1; mLin-2

Gene ID: 12361 | Gene type: protein coding

About Cask

Summary

Enables neurexin family protein binding activity. Involved in regulation of synaptic vesicle exocytosis. Acts upstream of or within calcium ion import; positive regulation of calcium ion import; and positive regulation of transcription by RNA polymerase II. Located in several cellular components, including basolateral plasma membrane; cell-cell junction; and cytosol. Is active in Schaffer collateral - CA1 synapse. Colocalizes with basement membrane. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in FG syndrome and syndromic X-linked intellectual disability Najm type. Orthologous to human CASK (calcium/Calmodulin dependent serine protein kinase). [provided by Alliance of Genome Resources, Apr 2022]

Cask Products(4)

mRNA	Protein	Name
NM_001284503.1	NP_001271432.1	peripheral plasma membrane protein CASK isoform 1
NM_001284504.1	NP_001271433.1	peripheral plasma membrane protein CASK isoform 2
NM_001284505.1	NP_001271434.1	peripheral plasma membrane protein CASK isoform 3
NM_009806.3	NP_033936.2	peripheral plasma membrane protein CASK isoform 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables neurexin family protein binding	IDA IDA: Inferred from direct assay	18054859	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12093160	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within calcium ion import	IMP IMP: Inferred from mutant phenotype	18054859	MGI
acts upstream of or within establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	18054859	MGI
acts upstream of or within positive regulation of calcium ion import	IDA IDA: Inferred from direct assay	18054859	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	15584924	MGI
involved in regulation of synaptic vesicle exocytosis	IDA IDA: Inferred from direct assay	17287346	MGI
involved in regulation of synaptic vesicle exocytosis	IMP IMP: Inferred from mutant phenotype	17287346	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	17287346	MGI
is active in Schaffer collateral - CA1 synapse	IMP IMP: Inferred from mutant phenotype	17287346	MGI
colocalizes with basement membrane	IDA IDA: Inferred from direct assay	18664494	MGI
located in basement membrane	IDA IDA: Inferred from direct assay	18664494	MGI
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	12351654	MGI
located in cell-cell junction	IDA IDA: Inferred from direct assay	18664494	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	18664494	MGI
located in cytosol	IDA IDA: Inferred from direct assay	12202822	MGI
located in membrane	IDA IDA: Inferred from direct assay	18054859	MGI
located in nucleus	IDA IDA: Inferred from direct assay	18664494	MGI
located in synapse	IDA IDA: Inferred from direct assay	12202822	MGI
located in vesicle	IDA IDA: Inferred from direct assay	19036990	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

peripheral plasma membrane protein CASK

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-115719	NR162	Inhibitor	99.7%	Unkown
HY-RS01938	CASK Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18466	Cask Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24947	Cask Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cask	NCBI	NCBI:8573

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