2. Gene
  3. Calm1 - calmodulin 1 Gene

Calm1 - calmodulin 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as CaM; Calm; Cam1

Gene ID: 12313 | Gene type: protein coding

About Calm1

Summary

This gene encodes a member of the EF-hand calcium-binding protein family. The encoded protein acts as a calcium sensor and is involved in relaying signals to calcium-sensitive proteins, Enzymes and ion channels. The protein-calcium complex binds target proteins to regulate several cellular processes, including smooth muscle contraction, inflammation, Apoptosis and the immune response. Mutations in the human gene are associated with catecholaminergic polymorphic ventricular tachycardia and long QT syndrome 14. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]

Calm1 Products(2)

mRNA Protein Name
NM_001313934.1 NP_001300863.1 calmodulin-1 isoform 1
NM_009790.5 NP_033920.1 calmodulin-1 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
10620513 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within G2/M transition of mitotic cell cycle IDA
IDA: Inferred from direct assay
2469574 MGI
acts upstream of or within positive regulation of DNA binding IDA
IDA: Inferred from direct assay
10049721 MGI
involved in presynaptic endocytosis IDA
IDA: Inferred from direct assay
31628181 MGI
involved in presynaptic endocytosis IMP
IMP: Inferred from mutant phenotype
31628181 MGI
Cellular Component GO Annotation Evidence Reference Source
is active in calyx of Held IDA
IDA: Inferred from direct assay
31628181 MGI
is active in calyx of Held IMP
IMP: Inferred from mutant phenotype
31628181 MGI
located in myelin sheath IDA
IDA: Inferred from direct assay
19855925 MGI
located in sperm midpiece IDA
IDA: Inferred from direct assay
29025071 MGI
part of voltage-gated potassium channel complex IGI
IGI: Inferred from genetic interaction
12223552 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

calmodulin-1

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01840 CALM1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS19989 Calm1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS26493 Calm1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Calm1 NCBI NCBI:801