2. Gene
  3. Ciita - class II transactivator Gene

Ciita - class II transactivator Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as C2ta; Gm9475; Mhc2ta; EG669998

Gene ID: 12265 | Gene type: protein coding

About Ciita

Summary

This gene encodes a member of the NOD-like Receptor protein family. This protein acts as a transcriptional coactivator and component of the enhanceosome complex to stimulate transcription of MHC class II genes in the adaptive immune response. This protein may also regulate the transcription of MHC class I genes. Mutations in the human gene have been linked to a rare immunodeficiency, bare lymphocyte syndrome, and homozygous knockout mice exhibit many features of this disease. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]

Ciita Products(5)

mRNA Protein Name
NM_001243760.2 NP_001230689.1 MHC class II transactivator isoform 1
NM_001243761.2 NP_001230690.1 MHC class II transactivator isoform 3
NM_001302618.1 NP_001289547.1 MHC class II transactivator isoform 4
NM_001302619.1 NP_001289548.1 MHC class II transactivator isoform 5
NM_007575.4 NP_031601.1 MHC class II transactivator isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
20211142 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within negative regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
15100295 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
32855215 MGI
acts upstream of or within response to type II interferon IDA
IDA: Inferred from direct assay
16280321 MGI
involved in response to type II interferon IDA
IDA: Inferred from direct assay
32855215 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

MHC class II transactivator

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02714 CIITA Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS19181 Ciita Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS25669 Ciita Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ciita NCBI NCBI:4261