2. Gene
  3. Bmp8a - bone morphogenetic protein 8a Gene

Bmp8a - bone morphogenetic protein 8a Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as OP2; OP-2; Bmp7r1

Gene ID: 12163 | Gene type: protein coding

About Bmp8a

Summary

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein may play a role in development of the reproductive system. Mice lacking a functional copy of this gene exhibit degeneration of germ cells and the epididymal epithelium. This gene may have arose from a gene duplication event and its gene duplicate is also present on chromosome 4. [provided by RefSeq, Jul 2016]

Bmp8a Products(2)

mRNA Protein Name
NM_001256019.1 NP_001242948.1 bone morphogenetic protein 8A isoform 1 precursor
NM_007558.3 NP_031584.1 bone morphogenetic protein 8A isoform 2 preproprotein
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within germ cell development IMP
IMP: Inferred from mutant phenotype
10894154 MGI
involved in osteoblast differentiation IDA
IDA: Inferred from direct assay
12925636 MGI
acts upstream of or within spermatogenesis IMP
IMP: Inferred from mutant phenotype
9463357 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

bone morphogenetic protein 8A

osteogenic protein 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01543 BMP8A Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS22407 Bmp8a Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS28931 Bmp8a Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bmp8a NCBI NCBI:353500