Bmp7 - bone morphogenetic protein 7 Gene

Mus musculus

Also known as OP1

Gene ID: 12162 | Gene type: protein coding

About Bmp7

Summary

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. Mutation of this gene results in skeletal, kidney, and Other developmental defects. [provided by RefSeq, Jul 2016]

Bmp7 Products(1)

mRNA	Protein	Name
NM_007557.3	NP_031583.2	bone morphogenetic protein 7 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12741987	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within BMP signaling pathway	IDA IDA: Inferred from direct assay	14623234	MGI
involved in allantois development	IGI IGI: Inferred from genetic interaction	10079236	MGI
acts upstream of ameloblast differentiation	IDA IDA: Inferred from direct assay	15525533	MGI
acts upstream of or within anatomical structure formation involved in morphogenesis	IMP IMP: Inferred from mutant phenotype	10049573	MGI
acts upstream of or within animal organ morphogenesis	IMP IMP: Inferred from mutant phenotype	7590254	MGI
acts upstream of or within axon guidance	IDA IDA: Inferred from direct assay	12741987	MGI
acts upstream of or within branching involved in salivary gland morphogenesis	IMP IMP: Inferred from mutant phenotype	11731698	MGI
acts upstream of or within branching morphogenesis of an epithelial tube	IDA IDA: Inferred from direct assay	15831470	MGI
acts upstream of or within camera-type eye morphogenesis	IMP IMP: Inferred from mutant phenotype	16154126	MGI
involved in cardiac muscle tissue development	IGI IGI: Inferred from genetic interaction	10079236	MGI
involved in cardiac septum morphogenesis	IGI IGI: Inferred from genetic interaction	10079236	MGI
acts upstream of or within cell development	IDA IDA: Inferred from direct assay	15831470	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	16854970	MGI
involved in chorio-allantoic fusion	IGI IGI: Inferred from genetic interaction	10079236	MGI
acts upstream of or within embryonic camera-type eye morphogenesis	IMP IMP: Inferred from mutant phenotype	10049573	MGI
acts upstream of or within embryonic limb morphogenesis	IGI IGI: Inferred from genetic interaction	9664686	MGI
acts upstream of or within embryonic limb morphogenesis	IMP IMP: Inferred from mutant phenotype	9664686	MGI
acts upstream of or within embryonic pattern specification	IMP IMP: Inferred from mutant phenotype	10049573	MGI
acts upstream of or within embryonic skeletal joint morphogenesis	IGI IGI: Inferred from genetic interaction	9664686	MGI
acts upstream of or within embryonic skeletal joint morphogenesis	IMP IMP: Inferred from mutant phenotype	9664686	MGI
involved in endocardial cushion formation	IGI IGI: Inferred from genetic interaction	10079236	MGI
acts upstream of or within epithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	17878916	MGI
involved in eye development	IMP IMP: Inferred from mutant phenotype	16154126	MGI
involved in heart trabecula morphogenesis	IGI IGI: Inferred from genetic interaction	10079236	MGI
involved in hindbrain development	IGI IGI: Inferred from genetic interaction	10079236	MGI
acts upstream of or within kidney development	IMP IMP: Inferred from mutant phenotype	16154126	MGI
involved in kidney development	IMP IMP: Inferred from mutant phenotype	16154126	MGI
acts upstream of mesenchymal cell apoptotic process involved in nephron morphogenesis	IMP IMP: Inferred from mutant phenotype	9056639	MGI
involved in mesenchyme development	IMP IMP: Inferred from mutant phenotype	9693150	MGI
acts upstream of or within mesoderm formation	IGI IGI: Inferred from genetic interaction	15843411	MGI
involved in metanephric mesenchymal cell proliferation involved in metanephros development	IGI IGI: Inferred from genetic interaction	15342483	MGI
involved in metanephric mesenchyme morphogenesis	IGI IGI: Inferred from genetic interaction	15342483	MGI
acts upstream of or within negative regulation of Notch signaling pathway	IGI IGI: Inferred from genetic interaction	16324690	MGI
acts upstream of or within negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	16854970	MGI
acts upstream of or within negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis	IMP IMP: Inferred from mutant phenotype	9056639	MGI
acts upstream of or within negative regulation of neurogenesis	IDA IDA: Inferred from direct assay	17699604	MGI
acts upstream of or within negative regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	16325379	MGI
acts upstream of or within negative regulation of prostatic bud formation	IDA IDA: Inferred from direct assay	16324690	MGI
involved in nephrogenic mesenchyme morphogenesis	IGI IGI: Inferred from genetic interaction	15342483	MGI
involved in neural fold elevation formation	IGI IGI: Inferred from genetic interaction	10079236	MGI
acts upstream of or within neuron projection morphogenesis	IMP IMP: Inferred from mutant phenotype	16325379	MGI
acts upstream of or within odontogenesis of dentin-containing tooth	IDA IDA: Inferred from direct assay	15525533	MGI
acts upstream of or within pattern specification process	IMP IMP: Inferred from mutant phenotype	7590254	MGI
involved in pericardium morphogenesis	IGI IGI: Inferred from genetic interaction	10079236	MGI
involved in pharyngeal system development	IGI IGI: Inferred from genetic interaction	10079236	MGI
acts upstream of or within positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	16854970	MGI
involved in positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis	IGI IGI: Inferred from genetic interaction	23863481	MGI
acts upstream of or within positive regulation of epithelial cell differentiation	IDA IDA: Inferred from direct assay	15525533	MGI
involved in positive regulation of epithelial to mesenchymal transition	IGI IGI: Inferred from genetic interaction	23863481	MGI
acts upstream of or within positive regulation of neuron differentiation	IDA IDA: Inferred from direct assay	9786991	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	16801560	MGI
acts upstream of or within regulation of branching involved in prostate gland morphogenesis	IMP IMP: Inferred from mutant phenotype	16324690	MGI
acts upstream of or within salivary gland morphogenesis	IMP IMP: Inferred from mutant phenotype	11731698	MGI
acts upstream of or within tube morphogenesis	IDA IDA: Inferred from direct assay	15831470	MGI
involved in ureteric bud development	IMP IMP: Inferred from mutant phenotype	9693150	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	12741987	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

bone morphogenetic protein 7

osteogenic protein 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-148234	M4K2234	Inhibitor	98.31%	Unkown
HY-RS01542	BMP7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17049	Bmp7 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23493	Bmp7 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Bmp7	NCBI	NCBI:655

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