Bmp5 - bone morphogenetic protein 5 Gene

Mus musculus

Also known as se

Gene ID: 12160 | Gene type: protein coding

About Bmp5

Summary

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Mice with null mutations in this gene exhibit a short ear phenotype, which is characterized by reduced size of the external ear, altered size and shape of the sternum, and Other skeletal and soft-tissue abnormalities. [provided by RefSeq, Jul 2016]

Bmp5 Products(1)

mRNA	Protein	Name
NM_007555.4	NP_031581.2	bone morphogenetic protein 5 preproprotein

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14660436	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in allantois development	IGI IGI: Inferred from genetic interaction	10079236	MGI
acts upstream of or within anterior head development	IMP IMP: Inferred from mutant phenotype	26234751	MGI
involved in cardiac muscle tissue development	IGI IGI: Inferred from genetic interaction	10079236	MGI
involved in cardiac septum morphogenesis	IGI IGI: Inferred from genetic interaction	10079236	MGI
involved in chorio-allantoic fusion	IGI IGI: Inferred from genetic interaction	10079236	MGI
acts upstream of or within ear development	IMP IMP: Inferred from mutant phenotype	26234751	MGI
involved in endocardial cushion formation	IGI IGI: Inferred from genetic interaction	10079236	MGI
involved in heart trabecula morphogenesis	IGI IGI: Inferred from genetic interaction	10079236	MGI
involved in hindbrain development	IGI IGI: Inferred from genetic interaction	10079236	MGI
acts upstream of or within male genitalia development	IGI IGI: Inferred from genetic interaction	9664685	MGI
involved in neural fold elevation formation	IGI IGI: Inferred from genetic interaction	10079236	MGI
acts upstream of or within pattern specification process	IMP IMP: Inferred from mutant phenotype	1339316	MGI
involved in pericardium morphogenesis	IGI IGI: Inferred from genetic interaction	10079236	MGI
involved in pharyngeal system development	IGI IGI: Inferred from genetic interaction	10079236	MGI
acts upstream of or within skeletal system development	IMP IMP: Inferred from mutant phenotype	1339316	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

bone morphogenetic protein 5

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01540	BMP5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19119	Bmp5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25609	Bmp5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Bmp5	NCBI	NCBI:653

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