Bmp10 - bone morphogenetic protein 10 Gene

Mus musculus

Also known as b2b2711Clo

Gene ID: 12154 | Gene type: protein coding

About Bmp10

Summary

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which binds to the activin receptor-like kinase 1 (ALK1) and plays important roles in cardiovascular development including cardiomyocyte proliferation and regulation of heart size, closure of the ductus arteriosus, angiogenesis and ventricular trabeculation. Homozygous knockout mice for this gene exhibit impaired heart development and embryonic lethality. [provided by RefSeq, Aug 2016]

Bmp10 Products(1)

mRNA	Protein	Name
NM_009756.3	NP_033886.2	bone morphogenetic protein 10 preproprotein

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Reference	Source
involved in BMP signaling pathway	IDA IDA: Inferred from direct assay	16798733	MGI
involved in adult heart development	IMP IMP: Inferred from mutant phenotype	16798733	MGI
involved in atrial cardiac muscle tissue morphogenesis	IEP IEP: Inferred from expression pattern	10072785	MGI
involved in cardiac muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	15073151	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	15073151	MGI
involved in heart trabecula formation	IMP IMP: Inferred from mutant phenotype	15073151	MGI
acts upstream of or within kidney development	IMP IMP: Inferred from mutant phenotype	27002738	MGI
involved in negative regulation of cardiac muscle hypertrophy	IMP IMP: Inferred from mutant phenotype	16798733	MGI
involved in positive regulation of SMAD protein signal transduction	IDA IDA: Inferred from direct assay	16798733	MGI
involved in positive regulation of cardiac muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	17336907	MGI
involved in positive regulation of cartilage development	IDA IDA: Inferred from direct assay	19956691	MGI
involved in positive regulation of cell proliferation involved in heart morphogenesis	IGI IGI: Inferred from genetic interaction	17336907	MGI
acts upstream of or within positive regulation of gene expression	IDA IDA: Inferred from direct assay	22783020	MGI
involved in ventricular cardiac muscle cell development	IDA IDA: Inferred from direct assay	16798733	MGI
involved in ventricular cardiac muscle tissue morphogenesis	IMP IMP: Inferred from mutant phenotype	15073151	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

bone morphogenetic protein 10

BMP-10

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01534	BMP10 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19175	Bmp10 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25664	Bmp10 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Bmp10	NCBI	NCBI:27302

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