Axin1 - axin 1 Gene

Mus musculus

Also known as Fu; Kb; Ki; Axin; fused; kinky; knobbly

Gene ID: 12005 | Gene type: protein coding

About Axin1

Summary

Enables several functions, including SMAD binding activity; beta-catenin binding activity; and enzyme binding activity. Involved in positive regulation of JNK cascade; positive regulation of protein modification process; and positive regulation of transcription, DNA-templated. Acts upstream of or within several processes, including chordate embryonic development; negative regulation of macromolecule metabolic process; and regulation of protein metabolic process. Located in several cellular components, including cell cortex; cytoplasmic vesicle; and microtubule Cytoskeleton. Part of Wnt signalosome and beta-catenin destruction complex. Is expressed in several structures, including alimentary system; forebrain; genitourinary system; hemolymphoid system gland; and retina. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human AXIN1 (axin 1). [provided by Alliance of Genome Resources, Apr 2022]

Axin1 Products(5)

mRNA	Protein	Name
NM_001159598.2	NP_001153070.2	axin-1 isoform 1
NM_001394381.1	NP_001381310.1	axin-1 isoform 2
NM_001394382.1	NP_001381311.1	axin-1 isoform 1
NM_001394389.1	NP_001381318.1	axin-1 isoform 1
NM_009733.3	NP_033863.3	axin-1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables I-SMAD binding	IDA IDA: Inferred from direct assay	16601693	MGI
enables I-SMAD binding	IPI IPI: Inferred from physical interaction	16601693	MGI
enables R-SMAD binding	IPI IPI: Inferred from physical interaction	16601693	MGI
enables beta-catenin binding	IPI IPI: Inferred from physical interaction	10318824	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	9920888	MGI
enables p53 binding	IPI IPI: Inferred from physical interaction	15526030	MGI
enables protein binding	IDA IDA: Inferred from direct assay	10318824	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9920888	MGI
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	15579909	MGI
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	17681137	MGI
enables protein kinase binding	IPI IPI: Inferred from physical interaction	10318824	MGI
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	16601693	MGI
enables ubiquitin-like ligase-substrate adaptor activity	IMP IMP: Inferred from mutant phenotype	16601693	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within Wnt signaling pathway	IDA IDA: Inferred from direct assay	11113207	MGI
acts upstream of or within Wnt signaling pathway	IPI IPI: Inferred from physical interaction	11113207	MGI
acts upstream of or within axial mesoderm development	IMP IMP: Inferred from mutant phenotype	9230313	MGI
acts upstream of or within axial mesoderm formation	IMP IMP: Inferred from mutant phenotype	9230313	MGI
acts upstream of or within canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	10937998	MGI
acts upstream of or within canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	19075000	MGI
acts upstream of or within cytoplasmic microtubule organization	IGI IGI: Inferred from genetic interaction	14734535	MGI
acts upstream of or within dorsal/ventral axis specification	IDA IDA: Inferred from direct assay	10330403	MGI
acts upstream of or within dorsal/ventral pattern formation	IMP IMP: Inferred from mutant phenotype	18316368	MGI
acts upstream of or within epigenetic programming in the zygotic pronuclei	IMP IMP: Inferred from mutant phenotype	12601169	MGI
acts upstream of or within head development	IMP IMP: Inferred from mutant phenotype	21344612	MGI
acts upstream of or within in utero embryonic development	IGI IGI: Inferred from genetic interaction	19204372	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	19204372	MGI
acts upstream of or within negative regulation of Wnt signaling pathway	IDA IDA: Inferred from direct assay	9230313	MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	15579909	MGI
acts upstream of or within negative regulation of fat cell differentiation	IDA IDA: Inferred from direct assay	10937998	MGI
acts upstream of or within negative regulation of gene expression	IDA IDA: Inferred from direct assay	18076571	MGI
acts upstream of or within negative regulation of protein metabolic process	IDA IDA: Inferred from direct assay	10330403	MGI
acts upstream of or within negative regulation of transcription elongation by RNA polymerase II	IDA IDA: Inferred from direct assay	10318824	MGI
acts upstream of or within nucleocytoplasmic transport	IDA IDA: Inferred from direct assay	14981260	MGI
acts upstream of or within positive regulation of JNK cascade	IMP IMP: Inferred from mutant phenotype	18316368	MGI
involved in positive regulation of JNK cascade	IMP IMP: Inferred from mutant phenotype	17681137	MGI
acts upstream of or within positive regulation of JUN kinase activity	IDA IDA: Inferred from direct assay	12878610	MGI
acts upstream of or within positive regulation of JUN kinase activity	IMP IMP: Inferred from mutant phenotype	12878610	MGI
involved in positive regulation of peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	11955436	MGI
involved in positive regulation of peptidyl-threonine phosphorylation	IDA IDA: Inferred from direct assay	11955436	MGI
acts upstream of or within positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	16601693	MGI
involved in positive regulation of protein kinase activity	IDA IDA: Inferred from direct assay	15526030	MGI
acts upstream of or within positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	10330403	MGI
acts upstream of or within positive regulation of protein ubiquitination	IDA IDA: Inferred from direct assay	16601693	MGI
acts upstream of or within positive regulation of protein ubiquitination	IGI IGI: Inferred from genetic interaction	16601693	MGI
acts upstream of or within positive regulation of protein ubiquitination	IMP IMP: Inferred from mutant phenotype	16601693	MGI
involved in positive regulation of protein ubiquitination	IMP IMP: Inferred from mutant phenotype	16601693	MGI
acts upstream of or within positive regulation of transforming growth factor beta receptor signaling pathway	IDA IDA: Inferred from direct assay	16601693	MGI
acts upstream of or within positive regulation of transforming growth factor beta receptor signaling pathway	IGI IGI: Inferred from genetic interaction	16601693	MGI
acts upstream of or within positive regulation of transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	16601693	MGI
acts upstream of or within positive regulation of ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	16601693	MGI
acts upstream of or within post-anal tail morphogenesis	IMP IMP: Inferred from mutant phenotype	12601169	MGI
acts upstream of or within protein catabolic process	IDA IDA: Inferred from direct assay	12717450	MGI
acts upstream of or within protein polyubiquitination	IDA IDA: Inferred from direct assay	16601693	MGI
acts upstream of or within regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	14981260	MGI
acts upstream of or within regulation of protein phosphorylation	IGI IGI: Inferred from genetic interaction	14734535	MGI
acts upstream of or within sensory perception of sound	IMP IMP: Inferred from mutant phenotype	21003499	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of Wnt signalosome	IDA IDA: Inferred from direct assay	22899650	MGI
part of beta-catenin destruction complex	IDA IDA: Inferred from direct assay	10318824	MGI
located in cell cortex	IDA IDA: Inferred from direct assay	10330403	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	11113207	MGI
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	11113207	MGI
located in microtubule cytoskeleton	IDA IDA: Inferred from direct assay	14734535	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	10330403	MGI
part of protein-containing complex	IDA IDA: Inferred from direct assay	16601693	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

axin-1

axis inhibition protein 1

protein Fused

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-147245	Basroparib	Inhibitor	98.49%	Phase 1

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-107528	FRATtide	Inhibitor	/	Unkown
HY-141543	YW2065	Inhibitor	99.91%	Unkown
HY-173349	TDI-012804	Inhibitor	/	Unkown
HY-RS01291	AXIN1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS22402	Axin1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Axin1	NCBI	NCBI:8312

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