2. Gene
  3. Atpif1 - ATPase inhibitory factor 1 Gene

Atpif1 - ATPase inhibitory factor 1 Gene

  • Gene
  • Protein
Mus musculus

Also known as If1; Atpi; IF(1); ATP5IF1

Gene ID: 11983 | Gene type: protein coding

About Atpif1

Summary

This gene encodes a member of the ATPase inhibitor family of proteins. This protein has been shown to negatively regulate the ATP hydrolysis activity of the F1Fo-ATPase. Knockdown of this gene is associated with reduced heme synthesis in differentiating erythroid cells. Misregulation of this gene has been found to lead to increased aerobic glycolysis in mouse Cancer cells, while high expression levels of this gene have been correlated with gastric and liver Cancer severity in human patients. A pseudogene of this gene has been identified. [provided by RefSeq, Apr 2015]

Atpif1 Products(1)

mRNA Protein Name
NM_007512.4 NP_031538.2 ATPase inhibitor, mitochondrial precursor
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
19096392 MGI
Biological Process GO Annotation Evidence Reference Source
involved in erythrocyte differentiation IMP
IMP: Inferred from mutant phenotype
23135403 MGI
involved in heme biosynthetic process IMP
IMP: Inferred from mutant phenotype
23135403 MGI
acts upstream of or within positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
19096392 MGI
acts upstream of or within reactive oxygen species metabolic process IMP
IMP: Inferred from mutant phenotype
19096392 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ATPase inhibitor, mitochondrial

ATP synthase F1 subunit epsilon

inhibitor of F(1)F(o)-ATPase