Atp7b - ATPase, Cu++ transporting, beta polypeptide Gene

Mus musculus

Also known as tx; WND; Atp7a

Gene ID: 11979 | Gene type: protein coding

About Atp7b

Summary

Enables P-type divalent copper transporter activity. Acts upstream of or within several processes, including cellular transition metal ion homeostasis; lactation; and protein maturation by copper ion transfer. Located in membrane and trans-Golgi network. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Used to study Wilson disease. Human ortholog(s) of this gene implicated in Wilson disease. Orthologous to human ATP7B (ATPase copper transporting beta). [provided by Alliance of Genome Resources, Apr 2022]

Atp7b Products(2)

mRNA	Protein	Name
NM_001403709.1	NP_001390638.1	copper-transporting ATPase 2 isoform 1
NM_007511.3	NP_031537.2	copper-transporting ATPase 2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables P-type divalent copper transporter activity	IDA IDA: Inferred from direct assay	11237756	MGI
enables P-type divalent copper transporter activity	IMP IMP: Inferred from mutant phenotype	11237756	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within copper ion transport	IDA IDA: Inferred from direct assay	11237756	MGI
acts upstream of or within copper ion transport	IMP IMP: Inferred from mutant phenotype	11085952	MGI
acts upstream of or within establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	11085952	MGI
acts upstream of or within intracellular copper ion homeostasis	IMP IMP: Inferred from mutant phenotype	1588441	MGI
acts upstream of or within intracellular zinc ion homeostasis	IMP IMP: Inferred from mutant phenotype	8040371	MGI
acts upstream of or within lactation	IMP IMP: Inferred from mutant phenotype	1588441	MGI
acts upstream of or within protein maturation by copper ion transfer	IMP IMP: Inferred from mutant phenotype	16436657	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in membrane	IDA IDA: Inferred from direct assay	10441329	MGI
located in trans-Golgi network	IDA IDA: Inferred from direct assay	11085952	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

copper-transporting ATPase 2

Wilson protein	copper pump 2
toxic milk	wilson disease-associated protein homolog

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01236	ATP7B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17601	Atp7b Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24061	Atp7b Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Atp7b	NCBI	NCBI:540

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