2. Gene
  3. Atp6v1a - ATPase, H+ transporting, lysosomal V1 subunit A Gene

Atp6v1a - ATPase, H+ transporting, lysosomal V1 subunit A Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as VA68; VPP2; Atp6a1; Atp6a2; Atp6v1a1

Gene ID: 11964 | Gene type: protein coding

About Atp6v1a

Summary

Enables proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in cellular iron ion homeostasis; cellular response to increased oxygen levels; and proton transmembrane transport. Predicted to act upstream of or within ion transport. Located in apical plasma membrane; cytosol; and microvillus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in autosomal recessive cutis laxa type IID and developmental and epileptic encephalopathy 93. Orthologous to human ATP6V1A (ATPase H+ transporting V1 subunit A). [provided by Alliance of Genome Resources, Apr 2022]

Atp6v1a Products(6)

mRNA Protein Name
NM_001358203.1 NP_001345132.1 V-type proton ATPase catalytic subunit A isoform 1
NM_001358204.1 NP_001345133.1 V-type proton ATPase catalytic subunit A isoform 1
NM_001413475.1 NP_001400404.1 V-type proton ATPase catalytic subunit A isoform 1
NM_001413476.1 NP_001400405.1 V-type proton ATPase catalytic subunit A isoform 1
NM_001413477.1 NP_001400406.1 V-type proton ATPase catalytic subunit A isoform 2
NM_007508.6 NP_031534.2 V-type proton ATPase catalytic subunit A isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables proton-transporting ATPase activity, rotational mechanism IMP
IMP: Inferred from mutant phenotype
23863464 MGI
Biological Process GO Annotation Evidence Reference Source
involved in synaptic vesicle lumen acidification EXP
EXP: Inferred from Experiment
28793259 MGI
involved in synaptic vesicle lumen acidification IDA
IDA: Inferred from direct assay
28793259 MGI
involved in synaptic vesicle lumen acidification IMP
IMP: Inferred from mutant phenotype
28793259 MGI
Cellular Component GO Annotation Evidence Reference Source
part of ATPase complex IDA
IDA: Inferred from direct assay
28793259 MGI
located in apical plasma membrane IDA
IDA: Inferred from direct assay
18667600 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
23863464 MGI
located in cytosol IDA
IDA: Inferred from direct assay
16177003 MGI
located in microvillus IDA
IDA: Inferred from direct assay
18667600 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
16177003 MGI
part of proton-transporting V-type ATPase complex IDA
IDA: Inferred from direct assay
12527205 MGI
part of proton-transporting V-type ATPase, V1 domain IDA
IDA: Inferred from direct assay
28793259 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

V-type proton ATPase catalytic subunit A

70-kDa subunit

ATPase, H+ transporting, V1 subunit A

ATPase, H+ transporting, V1 subunit A1

ATPase, H+ transporting, lysosomal (vacuolar proton pump), alpha 70 kDa

ATPase, H+ transporting, lysosomal 70kD, V1 subunit A

V-ATPase 69 kDa subunit

V-ATPas

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-128892 EN6 Activator 99.42% Unkown
HY-RS29446 ATP6V1A Monkey Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS01223 ATP6V1A Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS18574 Atp6v1a Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS25058 Atp6v1a Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Atp6v1a NCBI NCBI:523