2. Gene
  3. Asah1 - N-acylsphingosine amidohydrolase 1 Gene

Asah1 - N-acylsphingosine amidohydrolase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as AC; Asah; 2310081N20Rik

Gene ID: 11886 | Gene type: protein coding

About Asah1

Summary

This gene encodes acid Ceramidase, an enzyme that plays a central role in ceramide metabolism. The encoded protein undergoes proteolytic processing to generate a heterodimeric enzyme comprised of alpha and beta subunits that catalyzes the hydrolysis of sphingolipid ceramide into sphingosine and free fatty acid. The homozygous disruption of this gene leads to embryonic lethality in mice whereas the heterozygous Animals exhibit a progressive lipid storage disease phenotype. [provided by RefSeq, Oct 2015]

Asah1 Products(1)

mRNA Protein Name
NM_019734.3 NP_062708.1 acid ceramidase preproprotein
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables N-acylsphingosine amidohydrolase activity IDA
IDA: Inferred from direct assay
9653654 MGI
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to tumor necrosis factor IDA
IDA: Inferred from direct assay
10974027 MGI
involved in ceramide catabolic process IDA
IDA: Inferred from direct assay
9653654 MGI
involved in ceramide catabolic process IMP
IMP: Inferred from mutant phenotype
23770692 MGI
involved in regulation of programmed necrotic cell death IMP
IMP: Inferred from mutant phenotype
10974027 MGI
involved in sphingosine biosynthetic process IDA
IDA: Inferred from direct assay
9653654 MGI
Cellular Component GO Annotation Evidence Reference Source
located in nucleus IDA
IDA: Inferred from direct assay
22927646 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

acid ceramidase

ACDase

N-acylethanolamine hydrolase ASAH1

acid CDase

acylsphingosine deacylase

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-141866 Acid Ceramidase-IN-1 99.36% Unkown
HY-RS01053 ASAH1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-158783 SACLAC 99.70% Unkown
HY-RS18163 Asah1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS24637 Asah1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Asah1 NCBI NCBI:427