Aqp1 - aquaporin 1 Gene

Mus musculus

Also known as CHIP28

Gene ID: 11826 | Gene type: protein coding

About Aqp1

Summary

Enables Ephrin Receptor binding activity; potassium ion transmembrane transporter activity; and water transmembrane transporter activity. Involved in defense response to Gram-negative bacterium and potassium ion transport. Acts upstream of or within several processes, including corticotropin secretion; glomerular filtration; and metanephros development. Located in several cellular components, including basolateral plasma membrane; extracellular exosome; and symbiont-containing vacuole. Is integral component of membrane. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; sensory organ; and skeleton. Orthologous to human AQP1 (Aquaporin 1 (Colton blood group)). [provided by Alliance of Genome Resources, Apr 2022]

Aqp1 Products(1)

mRNA	Protein	Name
NM_007472.2	NP_031498.1	aquaporin-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ephrin receptor binding	IPI IPI: Inferred from physical interaction	10839360	MGI
enables potassium ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	18665841	MGI
enables water transmembrane transporter activity	IDA IDA: Inferred from direct assay	10644730	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within camera-type eye morphogenesis	IMP IMP: Inferred from mutant phenotype	11891232	MGI
acts upstream of cell migration	IMP IMP: Inferred from mutant phenotype	19298815	MGI
acts upstream of or within corticotropin secretion	IMP IMP: Inferred from mutant phenotype	18511498	MGI
involved in defense response to Gram-negative bacterium	IMP IMP: Inferred from mutant phenotype	18665841	MGI
acts upstream of or within establishment of localization in cell	IGI IGI: Inferred from genetic interaction	12133842	MGI
acts upstream of or within establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	10613915	MGI
acts upstream of fibroblast migration	IMP IMP: Inferred from mutant phenotype	19298815	MGI
acts upstream of or within glomerular filtration	IMP IMP: Inferred from mutant phenotype	15283758	MGI
involved in lateral ventricle development	IEP IEP: Inferred from expression pattern	16133142	MGI
acts upstream of or within lipid digestion	IMP IMP: Inferred from mutant phenotype	11121384	MGI
involved in metanephric descending thin limb development	IEP IEP: Inferred from expression pattern	18618131	MGI
involved in metanephric glomerulus vasculature development	IEP IEP: Inferred from expression pattern	18618131	MGI
involved in metanephric proximal convoluted tubule segment 2 development	IEP IEP: Inferred from expression pattern	18618131	MGI
involved in metanephric proximal straight tubule development	IEP IEP: Inferred from expression pattern	18618131	MGI
acts upstream of or within multicellular organismal-level water homeostasis	IMP IMP: Inferred from mutant phenotype	12034763	MGI
acts upstream of or within positive regulation of fibroblast migration	IMP IMP: Inferred from mutant phenotype	19298815	MGI
involved in potassium ion transport	IDA IDA: Inferred from direct assay	18665841	MGI
acts upstream of or within renal water absorption	IGI IGI: Inferred from genetic interaction	10662735	MGI
acts upstream of or within renal water absorption	IMP IMP: Inferred from mutant phenotype	9468475	MGI
acts upstream of or within secretion by cell	IMP IMP: Inferred from mutant phenotype	18511498	MGI
acts upstream of or within secretory granule organization	IMP IMP: Inferred from mutant phenotype	18511498	MGI
acts upstream of or within sensory perception of pain	IMP IMP: Inferred from mutant phenotype	16476579	MGI
acts upstream of or within water transport	IDA IDA: Inferred from direct assay	10644730	MGI
acts upstream of or within water transport	IGI IGI: Inferred from genetic interaction	12133842	MGI
acts upstream of or within water transport	IMP IMP: Inferred from mutant phenotype	9886922	MGI
acts upstream of or within wound healing	IMP IMP: Inferred from mutant phenotype	19298815	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	16133142	MGI
located in axon	IDA IDA: Inferred from direct assay	17257750	MGI
located in basal plasma membrane	IDA IDA: Inferred from direct assay	23238222	MGI
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	16133142	MGI
located in brush border	IDA IDA: Inferred from direct assay	16133142	MGI
located in caveola	IDA IDA: Inferred from direct assay	23238222	MGI
located in extracellular exosome	IDA IDA: Inferred from direct assay	19724054	MGI
located in membrane	IDA IDA: Inferred from direct assay	12181190	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	11078688	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

aquaporin-1

AQP-1	DER2
aquaporin-CHIP	delayed early response protein 2
growth factor-induced delayed early response protein	water channel protein for red blood cells and kidney proximal tubule

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N6016	Bacopaside II		98.69%	Unkown
HY-110200	TC AQP1 1	Inhibitor	98.51%	Unkown
HY-N2013	Aristolactam I		99.31%	Unkown
HY-174166	AqF026	Inhibitor	/	Unkown
HY-RS00871	AQP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17735	Aqp1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24200	Aqp1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Aqp1	NCBI	NCBI:358

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