2. Gene
  3. Aprt - adenine phosphoribosyl transferase Gene

Aprt - adenine phosphoribosyl transferase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus
Gene ID: 11821 | Gene type: protein coding

About Aprt

Summary

Enables adenine binding activity and adenine phosphoribosyltransferase activity. Involved in AMP salvage; GMP salvage; and IMP salvage. Acts upstream of or within adenine metabolic process; grooming behavior; and purine ribonucleoside salvage. Located in cytosol. Is expressed in several structures, including alimentary system; brain; cranium; genitourinary system; and sensory organ. Used to study adenine phosphoribosyltransferase deficiency. Human ortholog(s) of this gene implicated in adenine phosphoribosyltransferase deficiency. Orthologous to human APRT (adenine phosphoribosyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Aprt Products(1)

mRNA Protein Name
NM_009698.2 NP_033828.2 adenine phosphoribosyltransferase
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables adenine binding IDA
IDA: Inferred from direct assay
9218001 MGI
enables adenine phosphoribosyltransferase activity IDA
IDA: Inferred from direct assay
198184 MGI
enables adenine phosphoribosyltransferase activity IGI
IGI: Inferred from genetic interaction
8485579 MGI
enables adenine phosphoribosyltransferase activity IMP
IMP: Inferred from mutant phenotype
8485579 MGI
Biological Process GO Annotation Evidence Reference Source
involved in AMP salvage IDA
IDA: Inferred from direct assay
718989 MGI
acts upstream of or within AMP salvage IMP
IMP: Inferred from mutant phenotype
8864750 MGI
involved in AMP salvage IMP
IMP: Inferred from mutant phenotype
8864750 MGI
involved in GMP salvage IDA
IDA: Inferred from direct assay
718989 MGI
involved in IMP salvage IMP
IMP: Inferred from mutant phenotype
9776749 MGI
acts upstream of or within adenine metabolic process IGI
IGI: Inferred from genetic interaction
8894695 MGI
acts upstream of or within adenine metabolic process IMP
IMP: Inferred from mutant phenotype
8643571 MGI
NOT acts upstream of or within grooming behavior IGI
IGI: Inferred from genetic interaction
8894695 MGI
acts upstream of or within grooming behavior IGI
IGI: Inferred from genetic interaction
8485579 MGI
acts upstream of or within purine ribonucleoside salvage IGI
IGI: Inferred from genetic interaction
8485579 MGI
acts upstream of or within purine ribonucleoside salvage IMP
IMP: Inferred from mutant phenotype
8485579 MGI
Cellular Component GO Annotation Evidence Reference Source
is active in cytosol IDA
IDA: Inferred from direct assay
718989 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

adenine phosphoribosyltransferase

Related Agents

Pre-clinical Phase
Bioactive Molecules (10)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-119413 9-Ethyladenine Antagonist 99.93% Unkown
HY-N9941 2,8-Dihydroxyadenine 98.53% Unkown
HY-N5134S2 5'-Guanylic acid-15N5 dilithium ≥95.0% Unkown
HY-N5134S1 5'-Guanylic acid-13C10 dilithium / Unkown
HY-N5134S3 5'-Guanylic acid-d12 dilithium / Unkown
HY-RS00869 APRT Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-N5134S4 5'-Guanylic acid-15N5,d12 dilithium / Unkown
HY-N5134S5 5'-Guanylic acid-13C10,15N5 dilithium / Unkown
HY-RS18126 Aprt Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24600 Aprt Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Aprt NCBI NCBI:353