Nr2f2 - nuclear receptor subfamily 2, group F, member 2 Gene

Mus musculus

Also known as EAR3; ARP-1; SVP40; Aporp1; COUPTFB; COUP-TF2; Tcfcoup2; COUP-TFII; 2700033K02Rik; 9430015G03Rik

Gene ID: 11819 | Gene type: protein coding

About Nr2f2

Summary

Enables sequence-specific DNA binding activity. Acts upstream of or within several processes, including placenta development; regionalization; and vasculature development. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Used to study congenital diaphragmatic hernia and dilated cardiomyopathy. Human ortholog(s) of this gene implicated in 46,XX sex reversal 5. Orthologous to human NR2F2 (nuclear receptor subfamily 2 group F member 2). [provided by Alliance of Genome Resources, Apr 2022]

Nr2f2 Products(2)

mRNA	Protein	Name
NM_009697.3	NP_033827.2	COUP transcription factor 2 isoform 1
NM_183261.3	NP_899084.2	COUP transcription factor 2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	16912278	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	7823919	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within anterior/posterior pattern specification	IMP IMP: Inferred from mutant phenotype	15829524	MGI
acts upstream of or within blood vessel morphogenesis	IMP IMP: Inferred from mutant phenotype	15875024	MGI
acts upstream of or within fertilization	IMP IMP: Inferred from mutant phenotype	17404209	MGI
acts upstream of or within forebrain development	IDA IDA: Inferred from direct assay	15548577	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	17404209	MGI
acts upstream of or within interneuron migration	IDA IDA: Inferred from direct assay	15548577	MGI
involved in lymph vessel development	IEP IEP: Inferred from expression pattern	19210544	MGI
acts upstream of or within maternal placenta development	IMP IMP: Inferred from mutant phenotype	17404209	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	7823919	MGI
acts upstream of or within neuron migration	IDA IDA: Inferred from direct assay	15548577	MGI
acts upstream of or within placenta blood vessel development	IMP IMP: Inferred from mutant phenotype	17404209	MGI
acts upstream of or within radial pattern formation	IMP IMP: Inferred from mutant phenotype	15829524	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19796622	MGI
acts upstream of or within skeletal muscle tissue development	IMP IMP: Inferred from mutant phenotype	16251273	MGI
acts upstream of or within trophoblast giant cell differentiation	IMP IMP: Inferred from mutant phenotype	17404209	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	15548577	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

COUP transcription factor 2

COUP transcription factor II	COUP-TF II
apolipoprotein AI regulatory protein 1	apolipoprotein regulatory protein 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-156190A	NR2F2-IN-1 free base	Inhibitor	99.34%	Unkown
HY-156190	NR2F2-IN-1	Inhibitor	/	Unkown
HY-RS09542	NR2F2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20069	Nr2f2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26573	Nr2f2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nr2f2	NCBI	NCBI:7026

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