BAIAP2 - Baiap2 BAR/IMD domain containing adaptor protein 2 Gene

Rattus norvegicus

Also known as Irsp53

Gene ID: 117542 | Gene type: protein coding

About BAIAP2

Summary

Enables PDZ domain binding activity; scaffold protein binding activity; and transcription coregulator binding activity. Involved in several processes, including cellular response to L-glutamate; nervous system development; and regulation of synapse organization. Located in several cellular components, including dendrite; lamellipodium; and neuron projection branch point. Is active in several cellular components, including postsynaptic cytosol; postsynaptic density, intracellular component; and presynaptic cytosol. Colocalizes with postsynaptic density. Human ortholog(s) of this gene implicated in Gilles de la Tourette syndrome; attention deficit hyperactivity disorder; and autism spectrum disorder. Orthologous to human BAIAP2 (BAR/IMD domain containing adaptor protein 2). [provided by Alliance of Genome Resources, Apr 2022]

BAIAP2 Products(1)

mRNA	Protein	Name
NM_057196.1	NP_476544.1	brain-specific angiogenesis inhibitor 1-associated protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables PDZ domain binding	IDA IDA: Inferred from direct assay	14596909	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	14596909	RGD
enables scaffold protein binding	IPI IPI: Inferred from physical interaction	12421375	RGD
enables transcription coregulator binding	IPI IPI: Inferred from physical interaction	10332026	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to L-glutamate	IEP IEP: Inferred from expression pattern	15758177	RGD
involved in cellular response to epidermal growth factor stimulus	IEP IEP: Inferred from expression pattern	17855387	RGD
involved in neuron differentiation	IEP IEP: Inferred from expression pattern	25586189	RGD
involved in positive regulation of dendritic spine morphogenesis	IMP IMP: Inferred from mutant phenotype	15673667	RGD
involved in positive regulation of excitatory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	15758177	RGD
involved in positive regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	25586189	RGD
involved in protein localization to synapse	IMP IMP: Inferred from mutant phenotype	15758177	RGD
involved in regulation of modification of postsynaptic actin cytoskeleton	IDA IDA: Inferred from direct assay	15673667	RGD
involved in regulation of modification of postsynaptic actin cytoskeleton	IMP IMP: Inferred from mutant phenotype	15673667	RGD
involved in regulation of postsynapse organization	IDA IDA: Inferred from direct assay	15673667	RGD
involved in regulation of postsynapse organization	IMP IMP: Inferred from mutant phenotype	15673667	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in dendritic shaft	IDA IDA: Inferred from direct assay	24639075	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	15758177	RGD
located in dendritic spine cytoplasm	IDA IDA: Inferred from direct assay	15673667	RGD
located in excitatory synapse	IDA IDA: Inferred from direct assay	24639075	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	15673667	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	15673667	RGD
located in lamellipodium	IDA IDA: Inferred from direct assay	18480067	RGD
located in microtubule	IDA IDA: Inferred from direct assay	24639075	RGD
located in neuron projection branch point	IDA IDA: Inferred from direct assay	25586189	RGD
located in neuron projection terminus	IDA IDA: Inferred from direct assay	25586189	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	15758177	RGD
located in postsynapse	IDA IDA: Inferred from direct assay	15673667	RGD
is active in postsynaptic cytosol	IDA IDA: Inferred from direct assay	15673667	RGD
is active in postsynaptic density	IDA IDA: Inferred from direct assay	25293574	RGD
is active in postsynaptic density	IMP IMP: Inferred from mutant phenotype	25293574	RGD
is active in postsynaptic density, intracellular component	IDA IDA: Inferred from direct assay	15673667	RGD
located in presynapse	IDA IDA: Inferred from direct assay	15673667	RGD
is active in presynaptic cytosol	IDA IDA: Inferred from direct assay	15673667	RGD
located in secretory granule	IDA IDA: Inferred from direct assay	17120053	RGD
located in synaptic membrane	IDA IDA: Inferred from direct assay	15673667	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

brain-specific angiogenesis inhibitor 1-associated protein 2

BAI-associated protein 2	BAI1-associated protein 2
brain-specific angiogenesis inhibitor 1-associated protein 2-like	insulin receptor substrate 53
insulin receptor substrate p53	insulin receptor substrate protein of 53 kDa
insulin receptor tyrosine

BAIAP2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Baiap2	Q6GMN2	Lin7b	Rattus norvegicus	Q9Z252	Pull Down	14596909

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01353	BAIAP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01354	BAIAP2L1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01355	BAIAP2L2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21826	Baiap2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS28343	Baiap2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	BAIAP2	NCBI	NCBI:10458

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