Chd4 - chromodomain helicase DNA binding protein 4 Gene

Rattus norvegicus

Also known as Mi-2

Gene ID: 117535 | Gene type: protein coding

About Chd4

Summary

Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity; histone deacetylase binding activity; and transcription coregulator binding activity. Involved in negative regulation of transcription by RNA polymerase II and terminal button organization. Predicted to be located in centrosome; cytoplasm; and nucleoplasm. Predicted to be part of NuRD complex; RNA polymerase II transcription regulator complex; and protein-DNA complex. Orthologous to human CHD4 (chromodomain helicase DNA binding protein 4). [provided by Alliance of Genome Resources, Apr 2022]

Chd4 Products(7)

mRNA	Protein	Name
XM_006237396.4	XP_006237458.1	chromodomain-helicase-DNA-binding protein 4 isoform X1
XM_006237397.4	XP_006237459.1	chromodomain-helicase-DNA-binding protein 4 isoform X2
XM_006237401.4	XP_006237463.1	chromodomain-helicase-DNA-binding protein 4 isoform X3
XM_006237398.4	XP_006237460.1	chromodomain-helicase-DNA-binding protein 4 isoform X4
XM_006237400.4	XP_006237462.1	chromodomain-helicase-DNA-binding protein 4 isoform X7
XM_006237399.4	XP_006237461.1	chromodomain-helicase-DNA-binding protein 4 isoform X5
XM_232354.10	XP_232354.5	chromodomain-helicase-DNA-binding protein 4 isoform X6

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	18456662	RGD
involved in regulation of synapse assembly	IDA IDA: Inferred from direct assay	24991957	RGD
involved in regulation of synapse assembly	IMP IMP: Inferred from mutant phenotype	24991957	RGD
involved in terminal button organization	IMP IMP: Inferred from mutant phenotype	24991957	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in cerebellar granule cell to Purkinje cell synapse	IDA IDA: Inferred from direct assay	24991957	RGD
is active in cerebellar granule cell to Purkinje cell synapse	IMP IMP: Inferred from mutant phenotype	24991957	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

chromodomain-helicase-DNA-binding protein 4

Mi-2 autoantigen

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02609	CHD4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18917	Chd4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25407	Chd4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Chd4	NCBI	NCBI:1108

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