2. Gene
  3. Txnip - thioredoxin interacting protein Gene

Txnip - thioredoxin interacting protein Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Vdup1

Gene ID: 117514 | Gene type: protein coding

About Txnip

Summary

Predicted to enable enzyme inhibitor activity and ubiquitin protein Ligase binding activity. Involved in several processes, including response to estradiol; response to glucose; and response to progesterone. Located in mitochondrial intermembrane space and nucleus. Used to study renal cell carcinoma. Biomarker of colorectal cancer; glaucoma; and stomach Cancer. Orthologous to human TXNIP (thioredoxin interacting protein). [provided by Alliance of Genome Resources, Apr 2022]

Txnip Products(1)

mRNA Protein Name
NM_001008767.2 NP_001008767.1 thioredoxin-interacting protein
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
16172122 RGD
involved in regulation of cell population proliferation IDA
IDA: Inferred from direct assay
12011048 RGD
involved in response to calcium ion IEP
IEP: Inferred from expression pattern
11579135 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
15047938 RGD
involved in response to glucose IEP
IEP: Inferred from expression pattern
12213820 RGD
involved in response to hydrogen peroxide IEP
IEP: Inferred from expression pattern
12011048 RGD
involved in response to mechanical stimulus IEP
IEP: Inferred from expression pattern
12011048 RGD
involved in response to progesterone IEP
IEP: Inferred from expression pattern
15047938 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
16782054 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

thioredoxin-interacting protein

upregulated by 1,25-dihydroxyvitamin D-3

vitamin D3 up-regulated protein 1

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0004 Doxofylline 99.40% Yes
Pre-clinical Phase
Bioactive Molecules (15)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-19330 DASA-58 Activator 99.67% Unkown
HY-142114 SRI-37330 Inhibitor 99.16% Unkown
HY-141623 SRI-37330 hydrochloride Inhibitor 99.72% Unkown
HY-N0496 Ruscogenin Inhibitor 99.85% Unkown
HY-113328 Aminoadipic acid 99.86% Unkown
HY-115688 TXNIP-IN-1 Inhibitor 98.90% Unkown
HY-122682 SBI-993 98.67% Unkown
HY-124418 SBI-477 Inhibitor 98.0% Unkown
HY-155248 HL23 99.64% Unkown
HY-115688A (S)-TXNIP-IN-1 Control 99.73% Unkown
HY-RS15295 TXNIP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-149216 Anticancer agent 103 / Unkown
HY-169298 Ferroptosis-IN-15 Inhibitor / Unkown
HY-RS16561 Txnip Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22993 Txnip Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Txnip NCBI NCBI:10628