Slc25a5 - solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5 Gene

Mus musculus

Also known as Ant2

Gene ID: 11740 | Gene type: protein coding

About Slc25a5

Summary

This gene encodes a transmembrane domain-containing protein that localizes to the mitochondrial inner membrane. The encoded protein facilitates the exchange of ADP from the cytoplasm with ATP from the mitochondria. Pseudogenes for this gene are found on multiple chromosomes. [provided by RefSeq, May 2015]

Slc25a5 Products(1)

mRNA	Protein	Name
NM_007451.4	NP_031477.1	ADP/ATP translocase 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP:ADP antiporter activity	IDA IDA: Inferred from direct assay	31341297	MGI
enables ATP:ADP antiporter activity	IMP IMP: Inferred from mutant phenotype	31618756	MGI
enables oxidative phosphorylation uncoupler activity	IDA IDA: Inferred from direct assay	31341297	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	31618756	MGI
enables proton transmembrane transporter activity	IDA IDA: Inferred from direct assay	31341297	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in B cell differentiation	IMP IMP: Inferred from mutant phenotype	25613378	MGI
involved in adaptive thermogenesis	IMP IMP: Inferred from mutant phenotype	31341297	MGI
acts upstream of or within cellular response to leukemia inhibitory factor	IEP IEP: Inferred from expression pattern	20439489	MGI
involved in erythrocyte differentiation	IMP IMP: Inferred from mutant phenotype	25613378	MGI
involved in mitochondrial ADP transmembrane transport	IDA IDA: Inferred from direct assay	31341297	MGI
involved in mitochondrial ADP transmembrane transport	IMP IMP: Inferred from mutant phenotype	31618756	MGI
involved in mitochondrial ATP transmembrane transport	IDA IDA: Inferred from direct assay	31341297	MGI
involved in mitochondrial ATP transmembrane transport	IMP IMP: Inferred from mutant phenotype	31618756	MGI
involved in positive regulation of mitophagy	IDA IDA: Inferred from direct assay	31618756	MGI
involved in regulation of mitochondrial membrane permeability	IMP IMP: Inferred from mutant phenotype	31489369	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	28376086	MGI
part of mitochondrial permeability transition pore complex	IMP IMP: Inferred from mutant phenotype	31489369	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ADP/ATP translocase 2

ADP, ATP carrier protein 2	adenine nucleotide translocase
adenine nucleotide translocator 2, fibroblast

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13131	SLC25A5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20216	Slc25a5 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26723	Slc25a5 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc25a5	NCBI	NCBI:292

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