Eif4e - eukaryotic translation initiation factor 4E Gene

Rattus norvegicus

Gene ID: 117045 | Gene type: protein coding

About Eif4e

Summary

Enables eukaryotic initiation factor 4G binding activity. Involved in lung development. Part of eukaryotic translation initiation factor 4F complex. Is active in glutamatergic synapse and postsynaptic cytosol. Biomarker of vascular dementia. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human EIF4E (eukaryotic translation initiation factor 4E). [provided by Alliance of Genome Resources, Apr 2022]

Eif4e Products(1)

mRNA	Protein	Name
NM_053974.2	NP_446426.1	eukaryotic translation initiation factor 4E

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables eukaryotic initiation factor 4G binding	IPI IPI: Inferred from physical interaction	18952566	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	18952566	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in lung development	IEP IEP: Inferred from expression pattern	18952566	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of eukaryotic translation initiation factor 4F complex	IDA IDA: Inferred from direct assay	18952566	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	11756682	RGD
is active in postsynapse	IDA IDA: Inferred from direct assay	12711090	RGD
is active in postsynaptic cytosol	IDA IDA: Inferred from direct assay	11756682	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	18952566	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

eukaryotic translation initiation factor 4E

eIF-4E	eIF-4F 25 kDa subunit
eukaryotic initiation factor 4E	mRNA cap-binding protein

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-100022	Tomivosertib	Inhibitor	99.92%	Phase 2
HY-16366	Briciclib	Inhibitor	99.45%	Phase 1

Pre-clinical Phase

Bioactive Molecules (28)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19831	4EGI-1		98.32%	Unkown
HY-14427	4E1RCat	Inhibitor	98.89%	Unkown
HY-145974A	m7GpppAmpG ammonium		99.50%	Unkown
HY-145262	eIF4E-IN-2	Inhibitor	98.76%	Unkown
HY-100733	4E2RCat	Inhibitor	≥98.0%	Unkown
HY-119271	CMLD010509		99.11%	Unkown
HY-146805	EB1		99.91%	Unkown
HY-114267	Cbz-B3A	Inhibitor	98.63%	Unkown
HY-19831A	(Z)-4EGI-1	Inhibitor	≥98.0%	Unkown
HY-RS04274	EIF4E Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-145309	eIF4E-IN-3	Inhibitor	/	Unkown
HY-100022A	Tomivosertib hydrochloride	Inhibitor	/	Unkown
HY-145240	eIF4E-IN-1	Inhibitor	/	Unkown
HY-148664	eIF4E-IN-4	Inhibitor	/	Unkown
HY-155337	eIF4E-IN-6	Inhibitor	/	Unkown
HY-155676	eIF4E-IN-5	Inhibitor	/	Unkown
HY-163479	MNK1/2-IN-7	Inhibitor	/	Unkown
HY-176288	eIF4E/eIF4G PPI-IN-1		/	Unkown
HY-176428	PROTAC MNK1 degrader-1		/	Unkown
HY-RS04275	EIF4E2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04276	EIF4E3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W846144	ETP-45835	Inhibitor	/	Unkown
HY-119271A	(-)-CMLD010509		/	Unkown
HY-145974	m7GpppAmpG		/	Unkown
HY-168326	Antiproliferative agent-64	Inhibitor	/	Unkown
HY-172457	NUCC-0200808	Inhibitor	/	Unkown
HY-RS17829	Eif4e Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24297	Eif4e Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Eif4e	NCBI	NCBI:1977

Name
Email *

	Sorry, but the email address you supplied was invalid.