Amelx - amelogenin, X-linked Gene

Mus musculus

Also known as Amg; ALGN; AMGL; AMGX; Amel; LRAP; Rgsc888

Gene ID: 11704 | Gene type: protein coding

About Amelx

Summary

Enables several functions, including growth factor activity; hydroxyapatite binding activity; and metal ion binding activity. Involved in cell adhesion; enamel mineralization; and regulation of cell population proliferation. Acts upstream of or within odontogenesis of dentin-containing tooth. Located in basement membrane; cell surface; and supramolecular complex. Part of protein-containing complex. Is expressed in several structures, including connective tissue; eye; jaw; nervous system; and skeleton. Used to study amelogenesis imperfecta type 1E. Human ortholog(s) of this gene implicated in amelogenesis imperfecta and amelogenesis imperfecta type 1E. Orthologous to several human genes including AMELX (amelogenin X-linked). [provided by Alliance of Genome Resources, Apr 2022]

Amelx Products(3)

mRNA	Protein	Name
NM_001081978.2	NP_001075447.1	amelogenin, X isoform isoform 1 precursor
NM_001290371.1	NP_001277300.1	amelogenin, X isoform isoform 3 precursor
NM_009666.4	NP_033796.1	amelogenin, X isoform isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium ion binding	IDA IDA: Inferred from direct assay	19086270	MGI
enables growth factor activity	IMP IMP: Inferred from mutant phenotype	16674693	MGI
enables hydroxyapatite binding	IDA IDA: Inferred from direct assay	11852235	MGI
enables identical protein binding	IDA IDA: Inferred from direct assay	23896516	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	9041053	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11063033	MGI
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	19086270	MGI
enables sodium ion binding	IDA IDA: Inferred from direct assay	19086270	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in amelogenesis	IDA IDA: Inferred from direct assay	26403673	MGI
involved in cell adhesion	IMP IMP: Inferred from mutant phenotype	16674693	MGI
involved in enamel mineralization	IDA IDA: Inferred from direct assay	26403673	MGI
involved in odontogenesis of dentin-containing tooth	IEP IEP: Inferred from expression pattern	16674683	MGI
involved in regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	16674693	MGI
involved in tooth mineralization	IMP IMP: Inferred from mutant phenotype	11406633	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in basement membrane	IDA IDA: Inferred from direct assay	18757743	MGI
located in cell surface	IMP IMP: Inferred from mutant phenotype	16674683	MGI
part of protein-containing complex	IDA IDA: Inferred from direct assay	19086270	MGI
located in supramolecular complex	IDA IDA: Inferred from direct assay	20304108	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

amelogenin, X isoform

amelogenin X chromosome	enamel matrix protein
leucine-rich amelogenin peptide

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00647	AMELX Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19982	Amelx Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26486	Amelx Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Amelx	NCBI	NCBI:265

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