2. Gene
  3. Bin1 - bridging integrator 1 Gene

Bin1 - bridging integrator 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 117028 | Gene type: protein coding

About Bin1

Summary

Enables GTPase binding activity. Involved in positive regulation of GTPase activity; positive regulation of endocytosis; and synaptic vesicle endocytosis. Located in several cellular components, including T-tubule; Z disc; and axon. Is active in glutamatergic synapse. Is extrinsic component of synaptic vesicle membrane. Human ortholog(s) of this gene implicated in breast carcinoma; centronuclear myopathy 2; and prostate adenocarcinoma. Orthologous to human BIN1 (bridging integrator 1). [provided by Alliance of Genome Resources, Apr 2022]

Bin1 Products(1)

mRNA Protein Name
NM_053959.2 NP_446411.1 myc box-dependent-interacting protein 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables GTPase binding IPI
IPI: Inferred from physical interaction
9348539 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
9341169 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
9348539 RGD
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of GTPase activity IDA
IDA: Inferred from direct assay
9348539 RGD
involved in positive regulation of endocytosis IMP
IMP: Inferred from mutant phenotype
9348539 RGD
involved in synaptic vesicle endocytosis IDA
IDA: Inferred from direct assay
9348539 RGD
involved in synaptic vesicle endocytosis IMP
IMP: Inferred from mutant phenotype
9348539 RGD
Cellular Component GO Annotation Evidence Reference Source
located in I band IDA
IDA: Inferred from direct assay
9182667 RGD
located in T-tubule IDA
IDA: Inferred from direct assay
9182667 RGD
located in Z disc IDA
IDA: Inferred from direct assay
9182667 RGD
located in axon initial segment IDA
IDA: Inferred from direct assay
9182667 RGD
located in axon terminus IDA
IDA: Inferred from direct assay
9348539 RGD
located in cerebellar mossy fiber IDA
IDA: Inferred from direct assay
9348539 RGD
is active in extrinsic component of synaptic vesicle membrane IDA
IDA: Inferred from direct assay
9348539 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
9348539 RGD
located in node of Ranvier IDA
IDA: Inferred from direct assay
9182667 RGD
located in synaptic vesicle IDA
IDA: Inferred from direct assay
9348539 RGD
located in varicosity IDA
IDA: Inferred from direct assay
9348539 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

myc box-dependent-interacting protein 1

Amph2

amphiphysin II

amphiphysin IIamph2

amphiphysin-like protein

Related Agents

Pre-clinical Phase
Bioactive Molecules (18)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10704 PTP1B-IN-1 Inhibitor 99.65% Unkown
HY-139560 KDM2B-IN-1 Inhibitor 99.19% Unkown
HY-126246 CDC25B-IN-1 Inhibitor 98.09% Unkown
HY-135711 PDE8B-IN-1 / Unkown
HY-136556 Factor B-IN-1 Inhibitor ≥95.0% Unkown
HY-147646 CDK1/Cyc B-IN-1 98.47% Unkown
HY-162811 LAG-3 biner 1 97.08% Unkown
HY-117848 PDE8B-IN-1 hydrochloride Inhibitor / Unkown
HY-142957 NaPi2b-IN-1 Inhibitor / Unkown
HY-145695 Dual AChE-MAO B-IN-1 Inhibitor / Unkown
HY-147945 DNA gyrase B-IN-1 Inhibitor / Unkown
HY-163285 PDE3B-IN-1 Inhibitor / Unkown
HY-168185 α-glucosidase/PTP1B-IN-1 Inhibitor / Unkown
HY-RS01504 BIN1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-170412 Cox B-IN-1 Inhibitor / Unkown
HY-170810 E.coli Gyrase B-IN-1 Inhibitor / Unkown
HY-RS18913 Bin1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS25404 Bin1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bin1 NCBI NCBI:274