2. Gene
  3. Kcnh2 - potassium voltage-gated channel subfamily H member 2 Gene

Kcnh2 - potassium voltage-gated channel subfamily H member 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as ERG1

Gene ID: 117018 | Gene type: protein coding

About Kcnh2

Summary

Enables inward rectifier Potassium Channel activity and scaffold protein binding activity. Involved in central nervous system development; potassium ion transport; and regulation of membrane potential. Is integral component of plasma membrane. Human ortholog(s) of this gene implicated in long QT syndrome; long QT syndrome 2; and short QT syndrome. Orthologous to human KCNH2 (potassium voltage-gated channel subfamily H member 2). [provided by Alliance of Genome Resources, Apr 2022]

Kcnh2 Products(1)

mRNA Protein Name
NM_053949.1 NP_446401.1 potassium voltage-gated channel subfamily H member 2
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables inward rectifier potassium channel activity IDA
IDA: Inferred from direct assay
9664620 RGD
enables monoatomic ion channel activity IDA
IDA: Inferred from direct assay
11804849 RGD
enables potassium channel activity IDA
IDA: Inferred from direct assay
11804849 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
22879586 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
11212207 RGD
enables scaffold protein binding IPI
IPI: Inferred from physical interaction
18923542 RGD
enables voltage-gated potassium channel activity IDA
IDA: Inferred from direct assay
15677682 RGD
Biological Process GO Annotation Evidence Reference Source
involved in potassium ion transport IDA
IDA: Inferred from direct assay
9390998 RGD
involved in regulation of membrane potential IDA
IDA: Inferred from direct assay
11804849 RGD
involved in spinal cord development IEP
IEP: Inferred from expression pattern
15365256 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

potassium voltage-gated channel subfamily H member 2

ERG-1

RERG

eag-related protein 1

ether-a-go-go-related gene potassium channel 1

ether-a-go-go-related protein 1

potassium channel, voltage gated eag related subfamily H, member 2

potassium voltage-gated channel, subfamily H (eag-related), member 2

Related Agents

Approval
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0437 Sotalol hydrochloride 99.93% Unkown
HY-103196 Sotalol Inhibitor / Unkown
Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-16697 CID 16020046 Antagonist 99.81% Unkown
HY-N0267 Hypaconitine 99.49% Unkown
HY-B0437AS Sotalol-d6 hydrochloride ≥99.0% Unkown
HY-B0437S Sotalol-d6 Inhibitor / Unkown
HY-RS07126 KCNH2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS16857 Kcnh2 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23298 Kcnh2 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kcnh2 NCBI NCBI:3757