2. Gene
  3. Akr1b3 - aldo-keto reductase family 1, member B3 (aldose reductase) Gene

Akr1b3 - aldo-keto reductase family 1, member B3 (aldose reductase) Gene

  • Gene
  • Protein
Mus musculus

Also known as AR; ALR2; Ahr1; Ahr-1; Aldr1; Akr1b1; Aldor1

Gene ID: 11677 | Gene type: protein coding

About Akr1b3

Summary

Enables alditol:NADP+ 1-oxidoreductase activity. Acts upstream of or within several processes, including epithelial cell maturation; metanephric collecting duct development; and renal water homeostasis. Predicted to be located in several cellular components, including Schmidt-Lanterman incisure; Schwann cell microvillus; and mast cell granule. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in arteriosclerosis; cataract; diabetic neuropathy; diabetic retinopathy; and type 2 diabetes mellitus. Orthologous to human AKR1B1 (aldo-keto reductase family 1 member B). [provided by Alliance of Genome Resources, Apr 2022]

Akr1b3 Products(1)

mRNA Protein Name
NM_009658.3 NP_033788.3 aldo-keto reductase family 1 member B1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables L-glucuronate reductase activity IMP
IMP: Inferred from mutant phenotype
20410296 MGI
enables aldose reductase (NADPH) activity IDA
IDA: Inferred from direct assay
7851421 MGI
enables aldose reductase (NADPH) activity IMP
IMP: Inferred from mutant phenotype
17727625 MGI
Biological Process GO Annotation Evidence Reference Source
involved in L-ascorbic acid biosynthetic process IMP
IMP: Inferred from mutant phenotype
20410296 MGI
acts upstream of or within epithelial cell maturation IMP
IMP: Inferred from mutant phenotype
16449351 MGI
involved in fructose biosynthetic process IMP
IMP: Inferred from mutant phenotype
17727625 MGI
acts upstream of or within metanephric collecting duct development IMP
IMP: Inferred from mutant phenotype
16449351 MGI
acts upstream of or within negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
16449351 MGI
acts upstream of or within regulation of urine volume IDA
IDA: Inferred from direct assay
16449351 MGI
acts upstream of or within regulation of urine volume IMP
IMP: Inferred from mutant phenotype
16449351 MGI
acts upstream of or within renal water homeostasis IMP
IMP: Inferred from mutant phenotype
16449351 MGI
Cellular Component GO Annotation Evidence Reference Source
is active in cytosol IDA
IDA: Inferred from direct assay
29238976 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

aldo-keto reductase family 1 member B1

aldehyde reductase 1

aldo-keto reductase family 1 member B3

aldo-keto reductase family 1, member B1 (aldose reductase)

aldose reductase