1. Gene
  2. Dusp6 - dual specificity phosphatase 6 Gene

Dusp6 - dual specificity phosphatase 6 Gene

Rattus norvegicus

Also known as Mkp3

Gene ID: 116663 | Gene type: protein coding

About Dusp6

Summary

Enables protein tyrosine/serine/threonine Phosphatase activity. Involved in several processes, including negative regulation of ERK1 and ERK2 cascade; positive regulation of cell death; and response to growth factor. Located in cytosol. Biomarker of brain ischemia; pancreatitis; and visual epilepsy. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 19 with or without anosmia. Orthologous to human DUSP6 (dual specificity Phosphatase 6). [provided by Alliance of Genome Resources, Apr 2022]

Dusp6 Products(1)

mRNA Protein Name
NM_053883.3 NP_446335.1 dual specificity protein phosphatase 6
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein tyrosine/serine/threonine phosphatase activity IDA
IDA: Inferred from direct assay
8631996 RGD
Biological Process GO Annotation Evidence Reference Source
involved in cell differentiation IEP
IEP: Inferred from expression pattern
8631996 RGD
involved in negative regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
8626780 RGD
involved in response to growth factor IEP
IEP: Inferred from expression pattern
9559664 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
17881770 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
11701771 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dual specificity protein phosphatase 6

MAP kinase phosphatase 3

MKP-3

mitogen-activated protein kinase phosphatase 3

Orthologs Information

Species Symbol Source ID
Homo sapiens Dusp6 NCBI NCBI:1848