Nlgn1 - neuroligin 1 Gene

Rattus norvegicus

Gene ID: 116647 | Gene type: protein coding

About Nlgn1

Summary

Enables several functions, including cell adhesion molecule binding activity; identical protein binding activity; and neurexin family protein binding activity. Involved in several processes, including modulation of chemical synaptic transmission; positive regulation of cellular component organization; and synapse organization. Acts upstream of or within synapse organization. Located in several cellular components, including Golgi apparatus; dendrite; and filopodium tip. Is active in glutamatergic synapse. Is integral component of postsynaptic specialization membrane. Biomarker of status epilepticus. Orthologous to human NLGN1 (neuroligin 1). [provided by Alliance of Genome Resources, Apr 2022]

Nlgn1 Products(1)

mRNA	Protein	Name
NM_053868.2	NP_446320.1	neuroligin-1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cell adhesion molecule binding	IPI IPI: Inferred from physical interaction	15797875	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	19730411	RGD
enables neurexin family protein binding	IPI IPI: Inferred from physical interaction	14522992	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	19730411	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	18093522	RGD
enables signaling receptor activity	IDA IDA: Inferred from direct assay	15797875	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in AMPA glutamate receptor clustering	IMP IMP: Inferred from mutant phenotype	21940442	RGD
involved in NMDA glutamate receptor clustering	IDA IDA: Inferred from direct assay	19450252	RGD
involved in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	IDA IDA: Inferred from direct assay	9325340	RGD
involved in cellular response to calcium ion	IDA IDA: Inferred from direct assay	14522992	RGD
involved in cytoskeletal matrix organization at active zone	IMP IMP: Inferred from mutant phenotype	19628693	RGD
NOT involved in inhibitory postsynaptic potential	IDA IDA: Inferred from direct assay	17582332	RGD
involved in long-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	23083734	RGD
involved in modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	25428619	RGD
involved in neuron cell-cell adhesion	IDA IDA: Inferred from direct assay	15797875	RGD
involved in neuron projection arborization	IGI IGI: Inferred from genetic interaction	22750515	RGD
involved in neuron projection development	IGI IGI: Inferred from genetic interaction	22750515	RGD
involved in positive regulation of dendritic spine development	IDA IDA: Inferred from direct assay	17582332	RGD
involved in positive regulation of dendritic spine development	IMP IMP: Inferred from mutant phenotype	15681343	RGD
involved in positive regulation of excitatory postsynaptic potential	IDA IDA: Inferred from direct assay	17582332	RGD
involved in positive regulation of excitatory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	19628693	RGD
involved in positive regulation of filopodium assembly	IDA IDA: Inferred from direct assay	12930820	RGD
involved in positive regulation of intracellular signal transduction	IDA IDA: Inferred from direct assay	17582332	RGD
involved in positive regulation of presynaptic active zone assembly	IDA IDA: Inferred from direct assay	15797875	RGD
involved in positive regulation of protein localization to synapse	IMP IMP: Inferred from mutant phenotype	15681343	RGD
involved in positive regulation of ruffle assembly	IDA IDA: Inferred from direct assay	12930820	RGD
involved in positive regulation of synapse assembly	IDA IDA: Inferred from direct assay	15797875	RGD
involved in positive regulation of synaptic transmission, GABAergic	IDA IDA: Inferred from direct assay	12930820	RGD
involved in positive regulation of synaptic transmission, glutamatergic	IDA IDA: Inferred from direct assay	19730411	RGD
involved in positive regulation of synaptic transmission, glutamatergic	IMP IMP: Inferred from mutant phenotype	19628693	RGD
involved in positive regulation of synaptic vesicle endocytosis	IMP IMP: Inferred from mutant phenotype	19628693	RGD
involved in positive regulation of synaptic vesicle exocytosis	IMP IMP: Inferred from mutant phenotype	19628693	RGD
involved in postsynaptic density protein 95 clustering	IDA IDA: Inferred from direct assay	19450252	RGD
involved in postsynaptic density protein 95 clustering	IMP IMP: Inferred from mutant phenotype	12930820	RGD
involved in presynaptic membrane assembly	IDA IDA: Inferred from direct assay	15797875	RGD
involved in protein targeting	IDA IDA: Inferred from direct assay	9278515	RGD
involved in regulation of AMPA receptor activity	IDA IDA: Inferred from direct assay	17582332	RGD
involved in regulation of NMDA receptor activity	IDA IDA: Inferred from direct assay	17582332	RGD
involved in regulation of NMDA receptor activity	IMP IMP: Inferred from mutant phenotype	19628693	RGD
involved in regulation of presynapse organization	EXP EXP: Inferred from Experiment	10892652	RGD
involved in regulation of presynapse organization	IDA IDA: Inferred from direct assay	10892652	RGD
involved in regulation of presynapse organization	IMP IMP: Inferred from mutant phenotype	10892652	RGD
involved in synapse assembly	IDA IDA: Inferred from direct assay	15797875	RGD
acts upstream of or within synapse organization	IDA IDA: Inferred from direct assay	15681343	RGD
involved in synaptic vesicle clustering	IDA IDA: Inferred from direct assay	20534458	RGD
involved in synaptic vesicle clustering	IMP IMP: Inferred from mutant phenotype	19628693	RGD
involved in synaptic vesicle transport	IMP IMP: Inferred from mutant phenotype	19628693	RGD
involved in terminal button organization	IMP IMP: Inferred from mutant phenotype	19628693	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	15519238	RGD
located in cell surface	IDA IDA: Inferred from direct assay	15797875	RGD
located in dendrite	IDA IDA: Inferred from direct assay	17582332	RGD
located in dendritic shaft	IDA IDA: Inferred from direct assay	22539981	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	15519238	RGD
located in filopodium tip	IDA IDA: Inferred from direct assay	19450252	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	9927700	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	15519238	RGD
is active in postsynaptic specialization membrane	IDA IDA: Inferred from direct assay	9927700	RGD
located in postsynaptic specialization membrane	IDA IDA: Inferred from direct assay	15519238	RGD
located in synapse	IDA IDA: Inferred from direct assay	9278515	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

neuroligin-1

neuroligin I

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09339	NLGN1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS19024	Nlgn1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS25513	Nlgn1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nlgn1	NCBI	NCBI:22871
Mus musculus	Nlgn1	NCBI	NCBI:192167

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