Eif4ebp1 - eukaryotic translation initiation factor 4E binding protein 1 Gene

Rattus norvegicus

Also known as PHAS-I

Gene ID: 116636 | Gene type: protein coding

About Eif4ebp1

Summary

Enables eukaryotic initiation factor 4E binding activity and protein Phosphatase 2A binding activity. Involved in several processes, including response to amino acid starvation; response to ethanol; and response to ischemia. Located in cytoplasm and nucleus. Part of protein-containing complex. Is active in glutamatergic synapse and postsynaptic cytosol. Used to study tuberous sclerosis. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human EIF4EBP1 (eukaryotic translation initiation factor 4E binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Eif4ebp1 Products(1)

mRNA	Protein	Name
NM_053857.2	NP_446309.1	eukaryotic translation initiation factor 4E-binding protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables eukaryotic initiation factor 4E binding	IPI IPI: Inferred from physical interaction	18952566	RGD
enables protein phosphatase 2A binding	IPI IPI: Inferred from physical interaction	16899564	RGD
enables translation initiation factor binding	IPI IPI: Inferred from physical interaction	11865047	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to hypoxia	IDA IDA: Inferred from direct assay	10100614	RGD
involved in lung development	IEP IEP: Inferred from expression pattern	18952566	RGD
involved in negative regulation of protein-containing complex assembly	IMP IMP: Inferred from mutant phenotype	11865047	RGD
involved in negative regulation of translational initiation	IMP IMP: Inferred from mutant phenotype	11865047	RGD
involved in response to amino acid starvation	IDA IDA: Inferred from direct assay	11500297	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	15388509	RGD
involved in response to ischemia	IEP IEP: Inferred from expression pattern	20736160	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	11756682	RGD
is active in postsynaptic cytosol	IDA IDA: Inferred from direct assay	11756682	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	18952566	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

eukaryotic translation initiation factor 4E-binding protein 1

4E-BP1	eIF4E-binding protein 1
phosphorylated heat- and acid-stable protein regulated by insulin 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04277	EIF4EBP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20227	Eif4ebp1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26734	Eif4ebp1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Eif4ebp1	NCBI	NCBI:1978

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