2. Gene
  3. Plod1 - procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 Gene

Plod1 - procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Plod

Gene ID: 116552 | Gene type: protein coding

About Plod1

Summary

Enables several functions, including L-ascorbic acid binding activity; ferrous iron binding activity; and procollagen-lysine 5-dioxygenase activity. Involved in cellular response to hormone stimulus; peptidyl-lysine hydroxylation; and response to hypoxia. Predicted to be located in rough endoplasmic reticulum membrane. Predicted to be part of catalytic complex. Predicted to be active in endoplasmic reticulum. Biomarker of hypothyroidism. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome kyphoscoliotic type 1. Orthologous to human PLOD1 (procollagen-lysine,2-oxoglutarate 5-dioxygenase 1). [provided by Alliance of Genome Resources, Apr 2022]

Plod1 Products(1)

mRNA Protein Name
NM_053827.2 NP_446279.2 procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables L-ascorbic acid binding IMP
IMP: Inferred from mutant phenotype
11714250 RGD
enables ferrous iron binding IMP
IMP: Inferred from mutant phenotype
11714250 RGD
enables peptide binding IDA
IDA: Inferred from direct assay
11714250 RGD
enables peptide binding IMP
IMP: Inferred from mutant phenotype
11714250 RGD
enables procollagen-lysine 5-dioxygenase activity IDA
IDA: Inferred from direct assay
11714250 RGD
enables procollagen-lysine 5-dioxygenase activity IMP
IMP: Inferred from mutant phenotype
11714250 RGD
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to hormone stimulus IEP
IEP: Inferred from expression pattern
15817667 RGD
involved in peptidyl-lysine hydroxylation IDA
IDA: Inferred from direct assay
7578263 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
14622280 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

procollagen-lysine,2-oxoglutarate 5-dioxygenase 1

LH1

lysyl hydroxylase 1

procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1

procollagen-lysine, 2-oxoglutarate 5-dioxygenase (lysine hydroxylase, Ehlers-Danlos syndrome type VI)

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10728 PLOD1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS21027 Plod1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS27544 Plod1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Plod1 NCBI NCBI:5351