Adsl - adenylosuccinate lyase Gene

Mus musculus

Also known as Adl; Asl

Gene ID: 11564 | Gene type: protein coding

About Adsl

Summary

This gene encodes a protein that is involved in adenosine monophosphate (AMP) biosynthesis and maintaining AMP levels in the muscle. The encoded enzyme catalyzes the release of fumarate during AMP biosynthesis by cleaving the substrates succinylaminoimidazole carboxamide (SAICA) ribotide to give aminoimidazole carboxamide (AICA) ribotide, and adenylosuccinate to give adenylate. In humans, this gene is associated with adenylosuccinate deficiency, a rare autosomal disorder resulting in a spectrum of neurological symptoms. A pseudogene associated with this gene is located on the X chromosome. [provided by RefSeq, Jan 2013]

Adsl Products(1)

mRNA	Protein	Name
NM_009634.6	NP_033764.2	adenylosuccinate lyase

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity	IMP IMP: Inferred from mutant phenotype	6480832	MGI
enables N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity	IDA IDA: Inferred from direct assay	5891253	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in 'de novo' AMP biosynthetic process	IDA IDA: Inferred from direct assay	5891253	MGI
involved in 'de novo' AMP biosynthetic process	IMP IMP: Inferred from mutant phenotype	6480832	MGI
involved in 'de novo' IMP biosynthetic process	IMP IMP: Inferred from mutant phenotype	6480832	MGI
involved in 'de novo' XMP biosynthetic process	IMP IMP: Inferred from mutant phenotype	6480832	MGI
involved in AMP salvage	IDA IDA: Inferred from direct assay	25681585	MGI
involved in GMP biosynthetic process	IMP IMP: Inferred from mutant phenotype	6480832	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

adenylosuccinate lyase

ASase	adenylosuccinase
adenylosuccinate lyase 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00418	ADSL Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18123	Adsl Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24597	Adsl Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Adsl	NCBI	NCBI:158

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