Adrb2 - adrenergic receptor, beta 2 Gene

Mus musculus

Also known as Badm; Gpcr7; Adrb-2

Gene ID: 11555 | Gene type: protein coding

About Adrb2

Summary

This intronless gene belongs to the G-protein-coupled receptor superfamily, which includes transmembrane proteins that play a role in signal transduction across biological membranes resulting in a variety of physiological responses. The encoded protein is a beta-2 Adrenergic Receptor which is activated by Catecholamine ligands such as adrenaline and epinephrine. The protein participates in the classical signaling pathway involving G protein, adenylyl cyclase, cAMP (3'-5'-cyclic adenosine monophosphate) and protein kinase A (PKA). In humans, this gene is implicated in susceptibility to nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq, Apr 2013]

Adrb2 Products(1)

mRNA	Protein	Name
NM_007420.3	NP_031446.2	beta-2 adrenergic receptor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables adenylate cyclase binding	IDA IDA: Inferred from direct assay	12297500	MGI
enables beta2-adrenergic receptor activity	IDA IDA: Inferred from direct assay	2834198	MGI
enables enzyme binding	IPI IPI: Inferred from physical interaction	19801680	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9235896	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	2834198	MGI
acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	15724149	MGI
acts upstream of or within bone resorption	IMP IMP: Inferred from mutant phenotype	15724149	MGI
acts upstream of or within brown fat cell differentiation	IGI IGI: Inferred from genetic interaction	12387862	MGI
involved in cellular response to amyloid-beta	IGI IGI: Inferred from genetic interaction	20395454	MGI
acts upstream of or within diet induced thermogenesis	IGI IGI: Inferred from genetic interaction	12161655	MGI
acts upstream of or within heat generation	IGI IGI: Inferred from genetic interaction	12161655	MGI
acts upstream of or within negative regulation of multicellular organism growth	IGI IGI: Inferred from genetic interaction	12387862	MGI
acts upstream of or within negative regulation of smooth muscle contraction	IGI IGI: Inferred from genetic interaction	12925702	MGI
acts upstream of or within norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	IGI IGI: Inferred from genetic interaction	10358009	MGI
acts upstream of or within norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	IMP IMP: Inferred from mutant phenotype	10358009	MGI
acts upstream of or within positive regulation of bone mineralization	IMP IMP: Inferred from mutant phenotype	15724149	MGI
involved in positive regulation of cAMP/PKA signal transduction	IGI IGI: Inferred from genetic interaction	20395454	MGI
involved in positive regulation of cold-induced thermogenesis	IGI IGI: Inferred from genetic interaction	12387862	MGI
involved in positive regulation of mini excitatory postsynaptic potential	IGI IGI: Inferred from genetic interaction	20395454	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	15724149	MGI
acts upstream of or within regulation of sodium ion transport	IMP IMP: Inferred from mutant phenotype	15016730	MGI
acts upstream of or within regulation of systemic arterial blood pressure by norepinephrine-epinephrine	IMP IMP: Inferred from mutant phenotype	10358008	MGI
acts upstream of or within response to cold	IGI IGI: Inferred from genetic interaction	12161655	MGI
acts upstream of smooth muscle contraction	IGI IGI: Inferred from genetic interaction	12925702	MGI
acts upstream of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	15724149	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	14625387	MGI
located in membrane	IDA IDA: Inferred from direct assay	2834198	MGI
is active in neuronal dense core vesicle	EXP EXP: Inferred from Experiment	21321602	MGI
is active in neuronal dense core vesicle	IDA IDA: Inferred from direct assay	21321602	MGI
located in nucleus	IDA IDA: Inferred from direct assay	15791602	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

beta-2 adrenergic receptor

beta 2-AR	beta-2 adrenoceptor
beta-2 adrenoreceptor

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-14299	Indacaterol	Agonist	99.98%	Unkown
HY-14299A	Indacaterol maleate	Agonist	99.82%	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-14299D	Indacaterol acetate	Agonist	/	Phase 4

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13338	Mabuterol	Agonist	99.96%	Unkown
HY-RS00415	ADRB2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-14299B	(S)-Indacaterol		/	Unkown
HY-152051S	Mabuterol-d9 hydrochloride	Agonist	/	Unkown
HY-RS16956	Adrb2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23399	Adrb2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W755295	Mabuterol hydrochloride	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Adrb2	NCBI	NCBI:154

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