2. Gene
  3. Adcyap1 - adenylate cyclase activating polypeptide 1 Gene

Adcyap1 - adenylate cyclase activating polypeptide 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as PACAP

Gene ID: 11516 | Gene type: protein coding

About Adcyap1

Summary

This gene encodes a member of the glucagon superfamily of Hormones that have important roles in growth and metabolism. The encoded protein undergoes proteolytic processing to generate mature peptides that function as hypophysiotropic Hormones, neurotransmitters, neuromodulators and vasoregulators. Mice lacking the encoded protein exhibit a high rate of early mortality. The surviving adult Animals lacking the encoded protein exhibit decreased anxiety, hyperactive behavior and impaired steroidogenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015]

Adcyap1 Products(20)

mRNA Protein Name
NM_001315503.2 NP_001302432.1 pituitary adenylate cyclase-activating polypeptide isoform 1 preproprotein
NM_001315504.2 NP_001302433.1 pituitary adenylate cyclase-activating polypeptide isoform 2 preproprotein
NM_001409525.1 NP_001396454.1 pituitary adenylate cyclase-activating polypeptide isoform 3 preproprotein
NM_001409527.1 NP_001396456.1 pituitary adenylate cyclase-activating polypeptide isoform 3 preproprotein
NM_001409528.1 NP_001396457.1 pituitary adenylate cyclase-activating polypeptide isoform 1 preproprotein
NM_001409530.1 NP_001396459.1 pituitary adenylate cyclase-activating polypeptide isoform 1 preproprotein
NM_001409531.1 NP_001396460.1 pituitary adenylate cyclase-activating polypeptide isoform 4
NM_001409532.1 NP_001396461.1 pituitary adenylate cyclase-activating polypeptide isoform 5
NM_001412216.1 NP_001399145.1 pituitary adenylate cyclase-activating polypeptide isoform 2 preproprotein
NM_009625.4 NP_033755.1 pituitary adenylate cyclase-activating polypeptide isoform 1 preproprotein
NM_001315503.2 NP_001302432.1 pituitary adenylate cyclase-activating polypeptide isoform 1 preproprotein
NM_001315504.2 NP_001302433.1 pituitary adenylate cyclase-activating polypeptide isoform 2 preproprotein
NM_001409525.1 NP_001396454.1 pituitary adenylate cyclase-activating polypeptide isoform 3 preproprotein
NM_001409527.1 NP_001396456.1 pituitary adenylate cyclase-activating polypeptide isoform 3 preproprotein
NM_001409528.1 NP_001396457.1 pituitary adenylate cyclase-activating polypeptide isoform 1 preproprotein
NM_001409530.1 NP_001396459.1 pituitary adenylate cyclase-activating polypeptide isoform 1 preproprotein
NM_001409531.1 NP_001396460.1 pituitary adenylate cyclase-activating polypeptide isoform 4
NM_001409532.1 NP_001396461.1 pituitary adenylate cyclase-activating polypeptide isoform 5
NM_001412216.1 NP_001399145.1 pituitary adenylate cyclase-activating polypeptide isoform 2 preproprotein
NM_009625.4 NP_033755.1 pituitary adenylate cyclase-activating polypeptide isoform 1 preproprotein
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables pituitary adenylate cyclase activating polypeptide activity IDA
IDA: Inferred from direct assay
9603988 MGI
Biological Process GO Annotation Evidence Reference Source
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
9603988 MGI
involved in insulin secretion IDA
IDA: Inferred from direct assay
23913443 MGI
acts upstream of or within negative regulation of cell cycle IDA
IDA: Inferred from direct assay
12417650 MGI
involved in positive regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
12239106 MGI
acts upstream of or within positive regulation of gene expression IDA
IDA: Inferred from direct assay
23913443 MGI
involved in regulation of protein localization IDA
IDA: Inferred from direct assay
9603988 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

pituitary adenylate cyclase-activating polypeptide

Related Agents

Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00336 ADCYAP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS00337 ADCYAP1R1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS18214 Adcyap1r1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS19085 Adcyap1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS24691 Adcyap1r1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS25575 Adcyap1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P990777 Vipalanebart / Unkown
HY-P991123 Bocunebart Ligand / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Adcyap1 NCBI NCBI:116