Adamts1 - a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1 Gene

Mus musculus

Also known as C3-C5; METH1; ADAMTS; METH-1; ADAM-TS1; ADAMTS-1

Gene ID: 11504 | Gene type: protein coding

About Adamts1

Summary

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) family and preproprotein that is proteolytically processed to generate a mature protein product. This secreted protein product plays an important role in ovulation, likely through its cleavage of the extracellular matrix component versican. The encoded protein may enhance tumorigenesis in a mouse model of breast Cancer. Homozygous knockout mice for this gene exhibit enhanced perinatal lethality, impaired growth and adipose tissue development, and impaired ovulation in females. [provided by RefSeq, Oct 2015]

Adamts1 Products(1)

mRNA	Protein	Name
NM_009621.5	NP_033751.3	A disintegrin and metalloproteinase with thrombospondin motifs 1 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables heparin binding	IDA IDA: Inferred from direct assay	8995297	MGI
enables metalloendopeptidase activity	IDA IDA: Inferred from direct assay	16061471	MGI
enables metalloendopeptidase activity	IMP IMP: Inferred from mutant phenotype	16061471	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16061471	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within heart trabecula formation	IMP IMP: Inferred from mutant phenotype	18267097	MGI
acts upstream of or within kidney development	IMP IMP: Inferred from mutant phenotype	14668204	MGI
acts upstream of or within ovulation from ovarian follicle	IMP IMP: Inferred from mutant phenotype	14668204	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in basement membrane	IDA IDA: Inferred from direct assay	16061471	MGI
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	12907688	MGI
located in extracellular matrix	IDA IDA: Inferred from direct assay	9593739	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

A disintegrin and metalloproteinase with thrombospondin motifs 1

ADAM-TS 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00291	ADAMTS1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS19084	Adamts1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS25574	Adamts1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Adamts1	NCBI	NCBI:9510

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