Dusp1 - dual specificity phosphatase 1 Gene

Rattus norvegicus

Also known as Mkp1; CL100; MKP-1; 3CH134; Ptpn16

Gene ID: 114856 | Gene type: protein coding

About Dusp1

Summary

This gene encodes a protein that catalyzes the dephosphorylation and inactivation of MAP kinase, and may be involved in Insulin mediated signalling. [provided by RefSeq, Jul 2008]

Dusp1 Products(1)

mRNA	Protein	Name
NM_053769.4	NP_446221.2	dual specificity protein phosphatase 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables growth factor binding	IPI IPI: Inferred from physical interaction	18929742	RGD
enables protein tyrosine/threonine phosphatase activity	IDA IDA: Inferred from direct assay	12435803	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to hormone stimulus	IEP IEP: Inferred from expression pattern	15358679	RGD
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	11423551	RGD
involved in negative regulation of DNA biosynthetic process	IDA IDA: Inferred from direct assay	10446064	RGD
involved in negative regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	17437549	RGD
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	15059639	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	9228085	RGD
involved in protein dephosphorylation	IDA IDA: Inferred from direct assay	12435803	RGD
involved in response to cAMP	IEP IEP: Inferred from expression pattern	15358679	RGD
involved in response to calcium ion	IEP IEP: Inferred from expression pattern	11423551	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	8804359	RGD
involved in response to glucocorticoid	IEP IEP: Inferred from expression pattern	17403137	RGD
involved in response to hydrogen peroxide	IEP IEP: Inferred from expression pattern	7540516	RGD
involved in response to light stimulus	IEP IEP: Inferred from expression pattern	15527789	RGD
involved in response to retinoic acid	IEP IEP: Inferred from expression pattern	15494319	RGD
involved in response to testosterone	IEP IEP: Inferred from expression pattern	8804359	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

dual specificity protein phosphatase 1

3CH134/CL100 PTPase	MAP kinase phosphatase-1
mitogen-activated protein (MAP) kinase phosphatase-1	mitogen-activated protein kinase phosphatase 1
oxidative stress-inducible protein tyrosine phosphatase	protein-tyrosine phosphatase CL100
protein-tyros

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N2179	Hypaphorine	Inhibitor	99.97%	Unkown
HY-RS04050	DUSP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04053	DUSP12 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS16828	Dusp1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23270	Dusp1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dusp1	NCBI	NCBI:1843

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