2. Gene
  3. Phb2 - prohibitin 2 Gene

Phb2 - prohibitin 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Bap; Bap37; Bap-37; Bcap27; Bcap37

Gene ID: 114766 | Gene type: protein coding

About Phb2

Summary

Predicted to enable several functions, including protein C-terminus binding activity; protein N-terminus binding activity; and protein dimerization activity. Involved in several processes, including cellular response to hypoxia; cellular response to retinoic acid; and negative regulation of apoptotic process. Located in mitochondrion and nucleus. Is active in several cellular components, including GABA-ergic synapse; glutamatergic synapse; and postsynaptic density. Colocalizes with axon. Orthologous to human PHB2 (prohibitin 2). [provided by Alliance of Genome Resources, Apr 2022]

Phb2 Products(1)

mRNA Protein Name
NM_001013035.1 NP_001013053.1 prohibitin-2
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to hypoxia IEP
IEP: Inferred from expression pattern
25031298 RGD
involved in cellular response to retinoic acid IEP
IEP: Inferred from expression pattern
25031298 RGD
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
24566151 RGD
Cellular Component GO Annotation Evidence Reference Source
is active in GABA-ergic synapse EXP
EXP: Inferred from Experiment
23622064 RGD
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
23622064 RGD
located in axon IDA
IDA: Inferred from direct assay
23568660 RGD
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
17623647 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
17623647 RGD
located in mitochondrion IDA
IDA: Inferred from direct assay
19116139 RGD
is active in postsynaptic density EXP
EXP: Inferred from Experiment
17623647 RGD
is active in postsynaptic density IDA
IDA: Inferred from direct assay
17623647 RGD
is active in presynaptic active zone EXP
EXP: Inferred from Experiment
23622064 RGD
is active in presynaptic active zone IDA
IDA: Inferred from direct assay
23622064 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

prohibitin-2

B-cell receptor associated protein 37

B-cell receptor-associated protein BAP37

Related Agents

Pre-clinical Phase
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-114989 Fluorizoline Inducer 99.77% Unkown
HY-152093 YL-939 Inhibitor 99.03% Unkown
HY-117113 JI051 Inhibitor ≥98.0% Unkown
HY-124484 JI130 Inhibitor 99.01% Unkown
HY-162904 BPU17 / Unkown
HY-RS10408 PHB2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS16807 Phb2 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23247 Phb2 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Phb2 NCBI NCBI:11331
Macaca fascicularis Phb2 NCBI NCBI:102136314
Mus musculus Phb2 NCBI NCBI:12034