CYP27B1 - Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 Gene

Rattus norvegicus

Also known as Cyp40

Gene ID: 114700 | Gene type: protein coding

About CYP27B1

Summary

Enables calcidiol 1-monooxygenase activity. Involved in several processes, including negative regulation of bone trabecula formation; positive regulation of parathyroid hormone secretion; and vitamin D catabolic process. Located in mitochondrion. Used to study Wilson disease; acute kidney failure; nephrosis; and vitamin D-dependent rickets type 1A. Human ortholog(s) of this gene implicated in hepatitis B; obesity; rickets; type 1 diabetes mellitus; and vitamin D-dependent rickets type 1A. Orthologous to human CYP27B1 (Cytochrome P450 family 27 subfamily B member 1). [provided by Alliance of Genome Resources, Apr 2022]

CYP27B1 Products(1)

mRNA	Protein	Name
NM_053763.1	NP_446215.1	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcidiol 1-monooxygenase activity	IDA IDA: Inferred from direct assay	9333115	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in lactation	IEP IEP: Inferred from expression pattern	8333523	RGD
involved in negative regulation of bone trabecula formation	IMP IMP: Inferred from mutant phenotype	32231239	RGD
involved in negative regulation of ossification	IMP IMP: Inferred from mutant phenotype	32231239	RGD
involved in positive regulation of parathyroid hormone secretion	IMP IMP: Inferred from mutant phenotype	32231239	RGD
involved in response to cAMP	IDA IDA: Inferred from direct assay	6282936	RGD
involved in response to calcium ion	IEP IEP: Inferred from expression pattern	8333523	RGD
involved in response to copper ion	IDA IDA: Inferred from direct assay	3348368	RGD
involved in response to insulin	IDA IDA: Inferred from direct assay	3295473	RGD
involved in response to peptide hormone	IEP IEP: Inferred from expression pattern	10393981	RGD
involved in response to prostaglandin E	IDA IDA: Inferred from direct assay	3937586	RGD
involved in response to vitamin D	IDA IDA: Inferred from direct assay	3000565	RGD
involved in response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	3937586	RGD
involved in vitamin D catabolic process	IDA IDA: Inferred from direct assay	9333115	RGD
involved in vitamin D metabolic process	IDA IDA: Inferred from direct assay	9371776	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial

25-OHD-1 alpha-hydroxylase	25-hydroxyvitamin D(3) 1-alpha-hydroxylase
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial-like	P450C1 alpha
P450VD1-alpha	VD3 1A hydroxylase
calcidiol 1-monooxygenase	cytochrome P450 subfamily XXVIIB (25-hydroxyvi

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03451	CYP27B1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS16287	Cyp27b1 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS25766	Cyp27b1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	CYP27B1	NCBI	NCBI:1594

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