2. Gene
  3. Selenom - selenoprotein M Gene

Selenom - selenoprotein M Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Selm; Sepm; A230103K18; 1500040L08Rik

Gene ID: 114679 | Gene type: protein coding

About Selenom

Summary

The protein encoded by this gene belongs to the selenoprotein M/SEP15 family. The exact function of this protein is not known. It is localized in the perinuclear region, is highly expressed in the brain, and may be involved in neurodegenerative disorders. Transgenic mice with targeted deletion of this gene exhibit increased weight gain, suggesting a role for this gene in the regulation of body weight and energy metabolism. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Dec 2016]

Selenom Products(1)

mRNA Protein Name
NM_053267.3 NP_444497.1 selenoprotein M precursor
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within adipose tissue development IMP
IMP: Inferred from mutant phenotype
23880772 MGI
acts upstream of or within corticosterone secretion IMP
IMP: Inferred from mutant phenotype
23880772 MGI
acts upstream of or within hormone metabolic process IMP
IMP: Inferred from mutant phenotype
23880772 MGI
acts upstream of or within multicellular organism growth IMP
IMP: Inferred from mutant phenotype
23880772 MGI
acts upstream of or within response to selenium ion IMP
IMP: Inferred from mutant phenotype
23880772 MGI
Cellular Component GO Annotation Evidence Reference Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
11839807 MGI
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
11839807 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

selenoprotein M

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12638 SELENOM Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS20642 Selenom Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS27152 Selenom Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Selenom NCBI NCBI:140606