Suclg1 - succinate-CoA ligase GDP/ADP-forming subunit alpha Gene

Rattus norvegicus

Gene ID: 114597 | Gene type: protein coding

About Suclg1

Summary

Enables GDP binding activity; succinate-CoA Ligase (ADP-forming) activity; and succinate-CoA Ligase (GDP-forming) activity. Involved in succinate metabolic process; succinyl-CoA metabolic process; and tricarboxylic acid cycle. Located in mitochondrion. Part of succinate-CoA Ligase complex (GDP-forming). Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 9. Orthologous to human SUCLG1 (succinate-CoA Ligase GDP/ADP-forming subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]

Suclg1 Products(1)

mRNA	Protein	Name
NM_053752.2	NP_446204.2	succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GDP binding	IDA IDA: Inferred from direct assay	7430155	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	7430155	RGD
enables succinate-CoA ligase (ADP-forming) activity	IDA IDA: Inferred from direct assay	17403370	RGD
enables succinate-CoA ligase (GDP-forming) activity	IDA IDA: Inferred from direct assay	7430155	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in succinate metabolic process	IDA IDA: Inferred from direct assay	17403370	RGD
involved in succinyl-CoA metabolic process	IDA IDA: Inferred from direct assay	7430155	RGD
involved in tricarboxylic acid cycle	IDA IDA: Inferred from direct assay	17403370	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of protein-containing complex	IDA IDA: Inferred from direct assay	11831846	RGD
part of succinate-CoA ligase complex (GDP-forming)	IDA IDA: Inferred from direct assay	7430155	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial

SCS-alpha	succinate-CoA ligase, GDP-forming alpha subunit
succinate-CoA ligase, alpha subunit	succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial	succinyl-CoA synthetase al

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14001	SUCLG1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21202	Suclg1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS27718	Suclg1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Suclg1	NCBI	NCBI:8802

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