Nppc - natriuretic peptide C Gene

Rattus norvegicus

Gene ID: 114593 | Gene type: protein coding

About Nppc

Summary

Enables hormone activity. Involved in several processes, including negative regulation of biosynthetic process; positive regulation of cGMP-mediated signaling; and positive regulation of osteoblast differentiation. Acts upstream of or within receptor guanylyl cyclase signaling pathway. Located in extracellular space and secretory granule. Biomarker of aortic valve stenosis and heart disease. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human NPPC (natriuretic peptide C). [provided by Alliance of Genome Resources, Apr 2022]

Nppc Products(1)

mRNA	Protein	Name
NM_053750.1	NP_446202.1	C-type natriuretic peptide precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables hormone activity	IDA IDA: Inferred from direct assay	12746286	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cGMP-mediated signaling	IDA IDA: Inferred from direct assay	14691198	RGD
involved in negative regulation of DNA biosynthetic process	IDA IDA: Inferred from direct assay	12746286	RGD
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	17562543	RGD
involved in negative regulation of collagen biosynthetic process	IDA IDA: Inferred from direct assay	12746286	RGD
involved in positive regulation of cGMP-mediated signaling	IDA IDA: Inferred from direct assay	12746286	RGD
involved in positive regulation of mast cell degranulation	IDA IDA: Inferred from direct assay	9663691	RGD
involved in positive regulation of osteoblast differentiation	IDA IDA: Inferred from direct assay	17562543	RGD
involved in positive regulation of uterine smooth muscle relaxation	IDA IDA: Inferred from direct assay	9663691	RGD
acts upstream of or within receptor guanylyl cyclase signaling pathway	IDA IDA: Inferred from direct assay	17951249	RGD
involved in regulation of smooth muscle cell proliferation	IEP IEP: Inferred from expression pattern	11742834	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	9042593	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	16677483	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	11476746	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	16677483	RGD
located in secretory granule	IDA IDA: Inferred from direct assay	19666697	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

C-type natriuretic peptide

natriuretic peptide precursor C

natriuretic peptide precursor type C

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-176305S	Neurofilament, U-15N		/	Unkown
HY-RS09496	NPPC Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20311	Nppc Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26819	Nppc Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nppc	NCBI	NCBI:4880

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