2. Gene
  3. Itga6 - integrin subunit alpha 6 Gene

Itga6 - integrin subunit alpha 6 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 114517 | Gene type: protein coding

About Itga6

Summary

Enables laminin binding activity. Involved in cell-cell adhesion; cellular response to organic cyclic compound; and positive regulation of cell-substrate adhesion. Located in adherens junction and filopodium. Part of Integrin alpha6-beta4 complex. Human ortholog(s) of this gene implicated in junctional epidermolysis bullosa and junctional epidermolysis bullosa with pyloric atresia. Orthologous to human ITGA6 (Integrin subunit alpha 6). [provided by Alliance of Genome Resources, Apr 2022]

Itga6 Products(1)

mRNA Protein Name
NM_053725.2 NP_446177.2 integrin alpha-6 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables laminin binding IPI
IPI: Inferred from physical interaction
16608848 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
13130099 RGD
Biological Process GO Annotation Evidence Reference Source
involved in cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
16557522 RGD
involved in cellular response to organic cyclic compound IEP
IEP: Inferred from expression pattern
13130099 RGD
involved in positive regulation of cell-substrate adhesion IMP
IMP: Inferred from mutant phenotype
13130099 RGD
Cellular Component GO Annotation Evidence Reference Source
located in adherens junction IDA
IDA: Inferred from direct assay
16608848 RGD
located in filopodium IDA
IDA: Inferred from direct assay
13130099 RGD
part of integrin alpha6-beta4 complex IDA
IDA: Inferred from direct assay
13130099 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

integrin alpha-6

integrin, alpha 6

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06953 ITGA6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18523 Itga6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25005 Itga6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Itga6 NCBI NCBI:3655