Map2k6 - mitogen-activated protein kinase kinase 6 Gene

Rattus norvegicus

Also known as Mkk6

Gene ID: 114495 | Gene type: protein coding

About Map2k6

Summary

Enables MAP kinase kinase activity. Involved in several processes, including cellular response to sorbitol; positive regulation of macromolecule metabolic process; and response to ischemia. Predicted to be located in cytosol and nucleoplasm. Human ortholog(s) of this gene implicated in Pick's disease; cervical cancer; ovarian carcinoma; progressive supranuclear palsy; and restrictive cardiomyopathy. Orthologous to human MAP2K6 (mitogen-activated protein kinase kinase 6). [provided by Alliance of Genome Resources, Apr 2022]

Map2k6 Products(1)

mRNA	Protein	Name
NM_053703.3	NP_446155.1	dual specificity mitogen-activated protein kinase kinase 6

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables MAP kinase kinase activity	IDA IDA: Inferred from direct assay	20550965	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to sorbitol	IEP IEP: Inferred from expression pattern	20550965	RGD
involved in ovulation cycle process	IEP IEP: Inferred from expression pattern	11328854	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	12029621	RGD
involved in positive regulation of nitric-oxide synthase biosynthetic process	IMP IMP: Inferred from mutant phenotype	10593906	RGD
involved in positive regulation of prostaglandin secretion	IMP IMP: Inferred from mutant phenotype	12649265	RGD
involved in positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	20550965	RGD
involved in response to ischemia	IEP IEP: Inferred from expression pattern	20550965	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	16755153	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

dual specificity mitogen-activated protein kinase kinase 6

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08044	MAP2K6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17782	Map2k6 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24249	Map2k6 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Map2k6	NCBI	NCBI:5608

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