Dag1 - dystroglycan 1 Gene

Rattus norvegicus

Gene ID: 114489 | Gene type: protein coding

About Dag1

Summary

Enables laminin-1 binding activity. Involved in several processes, including calcium-dependent cell-matrix adhesion; cellular response to cholesterol; and nervous system development. Located in several cellular components, including basolateral plasma membrane; costamere; and focal adhesion. Part of dystrophin-associated glycoprotein complex. Is active in glutamatergic synapse and postsynaptic cytosol. Used to study myocardial infarction. Biomarker of muscular atrophy; primary biliary cholangitis; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Duchenne muscular dystrophy; autosomal recessive limb-girdle muscular dystrophy type 2D; autosomal recessive limb-girdle muscular dystrophy type 2P; congenital muscular dystrophy-dystroglycanopathy type A9; and inclusion body myositis. Orthologous to human DAG1 (dystroglycan 1). [provided by Alliance of Genome Resources, Apr 2022]

Dag1 Products(1)

mRNA	Protein	Name
NM_053697.1	NP_446149.1	dystroglycan precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables laminin binding	IDA IDA: Inferred from direct assay	8996823	RGD
enables laminin-1 binding	IDA IDA: Inferred from direct assay	9153251	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	15247274	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in Schwann cell differentiation	IEP IEP: Inferred from expression pattern	11869039	RGD
involved in angiogenesis involved in wound healing	IEP IEP: Inferred from expression pattern	21192954	RGD
involved in axon regeneration	IEP IEP: Inferred from expression pattern	16228655	RGD
involved in calcium-dependent cell-matrix adhesion	IMP IMP: Inferred from mutant phenotype	12177244	RGD
involved in cellular response to cholesterol	IEP IEP: Inferred from expression pattern	22613990	RGD
involved in cellular response to mechanical stimulus	IMP IMP: Inferred from mutant phenotype	18556591	RGD
involved in nerve development	IEP IEP: Inferred from expression pattern	16228655	RGD
involved in positive regulation of cell-matrix adhesion	IMP IMP: Inferred from mutant phenotype	9153251	RGD
involved in positive regulation of myelination	IMP IMP: Inferred from mutant phenotype	17395644	RGD
involved in positive regulation of oligodendrocyte differentiation	IMP IMP: Inferred from mutant phenotype	17395644	RGD
involved in positive regulation of protein kinase activity	IMP IMP: Inferred from mutant phenotype	18556591	RGD
involved in response to denervation involved in regulation of muscle adaptation	IEP IEP: Inferred from expression pattern	8906620	RGD
involved in response to peptide hormone	IEP IEP: Inferred from expression pattern	11416038	RGD
involved in skeletal muscle tissue regeneration	IEP IEP: Inferred from expression pattern	12086334	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in adherens junction	IDA IDA: Inferred from direct assay	9117347	RGD
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	11416038	RGD
located in costamere	IDA IDA: Inferred from direct assay	10531619	RGD
part of dystrophin-associated glycoprotein complex	IDA IDA: Inferred from direct assay	15247274	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	9153251	RGD
located in focal adhesion	IDA IDA: Inferred from direct assay	9117347	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	9446825	RGD
located in nuclear periphery	IDA IDA: Inferred from direct assay	21668890	RGD
located in plasma membrane raft	IDA IDA: Inferred from direct assay	22613990	RGD
is active in postsynaptic cytosol	IDA IDA: Inferred from direct assay	9446825	RGD
located in sarcolemma	IDA IDA: Inferred from direct assay	10531619	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

dystroglycan

alpha-dystroglycan	beta-dystroglycan
dystroglycan 1 (dystrophin-associated glycoprotein 1)

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W100403	Choline tosylate	Inhibitor	99.41%	Unkown
HY-RS03519	DAG1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18922	Dag1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS25412	Dag1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dag1	NCBI	NCBI:1605

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