Chrna7 - cholinergic receptor, nicotinic, alpha polypeptide 7 Gene

Mus musculus

Also known as Acra7; nAchR; alpha7

Gene ID: 11441 | Gene type: protein coding

About Chrna7

Summary

Enables acetylcholine-gated cation-selective channel activity. Involved in several processes, including plasma membrane bounded cell projection organization; positive regulation of cell communication; and regulation of protein metabolic process. Acts upstream of or within several processes, including behavioral response to ethanol; learning or memory; and negative regulation of cytokine production. Located in apical plasma membrane; axolemma; and external side of plasma membrane. Is integral component of postsynaptic specialization membrane and integral component of presynaptic membrane. Is active in cholinergic synapse. Is expressed in several structures, including adrenal gland; alimentary system; nervous system; retina; and thymus. Used to study schizophrenia. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to several human genes including CHRFAM7A (CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion). [provided by Alliance of Genome Resources, Apr 2022]

Chrna7 Products(1)

mRNA	Protein	Name
NM_007390.3	NP_031416.3	neuronal acetylcholine receptor subunit alpha-7 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables acetylcholine-gated monoatomic cation-selective channel activity	IDA IDA: Inferred from direct assay	9495872	MGI
enables acetylcholine-gated monoatomic cation-selective channel activity	IMP IMP: Inferred from mutant phenotype	9037516	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11906696	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within B cell activation	IMP IMP: Inferred from mutant phenotype	15963492	MGI
acts upstream of or within T cell activation	IMP IMP: Inferred from mutant phenotype	16253349	MGI
acts upstream of or within associative learning	IGI IGI: Inferred from genetic interaction	15541879	MGI
acts upstream of or within associative learning	IMP IMP: Inferred from mutant phenotype	15922075	MGI
acts upstream of or within behavioral response to ethanol	IMP IMP: Inferred from mutant phenotype	15489024	MGI
acts upstream of or within behavioral response to nicotine	IGI IGI: Inferred from genetic interaction	17470777	MGI
involved in dendrite arborization	IMP IMP: Inferred from mutant phenotype	23270857	MGI
involved in dendritic spine organization	IMP IMP: Inferred from mutant phenotype	23270857	MGI
acts upstream of or within endocytosis	IMP IMP: Inferred from mutant phenotype	16025111	MGI
acts upstream of or within establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	9364063	MGI
acts upstream of or within flagellated sperm motility	IMP IMP: Inferred from mutant phenotype	15944242	MGI
acts upstream of or within generation of ovulation cycle rhythm	IMP IMP: Inferred from mutant phenotype	15364017	MGI
acts upstream of interleukin-1 beta production	IMP IMP: Inferred from mutant phenotype	12508119	MGI
acts upstream of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	12508119	MGI
involved in learning or memory	IGI IGI: Inferred from genetic interaction	19118188	MGI
acts upstream of or within memory	IMP IMP: Inferred from mutant phenotype	16923147	MGI
involved in modulation of chemical synaptic transmission	IGI IGI: Inferred from genetic interaction	20943921	MGI
involved in modulation of excitatory postsynaptic potential	IDA IDA: Inferred from direct assay	20974225	MGI
involved in modulation of excitatory postsynaptic potential	IGI IGI: Inferred from genetic interaction	20974225	MGI
acts upstream of or within monoatomic ion transport	IMP IMP: Inferred from mutant phenotype	9364063	MGI
acts upstream of or within negative regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	16785311	MGI
acts upstream of or within negative regulation of interleukin-1 beta production	IMP IMP: Inferred from mutant phenotype	12508119	MGI
acts upstream of or within negative regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	12508119	MGI
involved in negative regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	19230830	MGI
acts upstream of or within negative regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	12508119	MGI
acts upstream of or within ovulation cycle	IMP IMP: Inferred from mutant phenotype	1400473	MGI
involved in positive regulation of CoA-transferase activity	IGI IGI: Inferred from genetic interaction	20164328	MGI
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	17898229	MGI
involved in positive regulation of ERK1 and ERK2 cascade	IGI IGI: Inferred from genetic interaction	20164328	MGI
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	11404397	MGI
involved in positive regulation of amyloid-beta formation	IGI IGI: Inferred from genetic interaction	20164328	MGI
involved in positive regulation of excitatory postsynaptic potential	IGI IGI: Inferred from genetic interaction	19118188	MGI
acts upstream of or within positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure	IMP IMP: Inferred from mutant phenotype	10942027	MGI
involved in positive regulation of long-term synaptic potentiation	IDA IDA: Inferred from direct assay	20974225	MGI
involved in positive regulation of long-term synaptic potentiation	IGI IGI: Inferred from genetic interaction	19118188	MGI
involved in positive regulation of peptidyl-serine phosphorylation	IMP IMP: Inferred from mutant phenotype	19230830	MGI
involved in positive regulation of protein metabolic process	IGI IGI: Inferred from genetic interaction	20164328	MGI
involved in positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	17898229	MGI
involved in regulation of amyloid fibril formation	IGI IGI: Inferred from genetic interaction	20164328	MGI
acts upstream of or within regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	12508119	MGI
acts upstream of or within regulation of membrane potential	IMP IMP: Inferred from mutant phenotype	9364063	MGI
acts upstream of or within regulation of norepinephrine secretion	IMP IMP: Inferred from mutant phenotype	10942027	MGI
involved in regulation of synapse structural plasticity	IMP IMP: Inferred from mutant phenotype	20164328	MGI
acts upstream of or within regulation of synaptic transmission, dopaminergic	IMP IMP: Inferred from mutant phenotype	16772172	MGI
involved in response to amyloid-beta	IMP IMP: Inferred from mutant phenotype	19118188	MGI
involved in response to cold	IDA IDA: Inferred from direct assay	19230830	MGI
acts upstream of or within response to ethanol	IMP IMP: Inferred from mutant phenotype	15555774	MGI
acts upstream of or within response to food	IMP IMP: Inferred from mutant phenotype	15922075	MGI
involved in response to nicotine	IGI IGI: Inferred from genetic interaction	11404397	MGI
acts upstream of or within response to nicotine	IMP IMP: Inferred from mutant phenotype	9495872	MGI
involved in sensory processing	IDA IDA: Inferred from direct assay	17898229	MGI
involved in synapse organization	IGI IGI: Inferred from genetic interaction	19587288	MGI
involved in synaptic transmission, cholinergic	IGI IGI: Inferred from genetic interaction	20164328	MGI
acts upstream of or within synaptic transmission, cholinergic	IMP IMP: Inferred from mutant phenotype	9364063	MGI
acts upstream of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	12508119	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	16033766	MGI
located in axolemma	IDA IDA: Inferred from direct assay	18458158	MGI
is active in cholinergic synapse	IDA IDA: Inferred from direct assay	12079404	MGI
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	15963492	MGI
located in membrane	IDA IDA: Inferred from direct assay	11834293	MGI
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	24607281	MGI
is active in postsynaptic membrane	IEP IEP: Inferred from expression pattern	24607281	MGI
is active in postsynaptic specialization membrane	IDA IDA: Inferred from direct assay	12079404	MGI
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	24607281	MGI
is active in presynaptic membrane	IEP IEP: Inferred from expression pattern	24607281	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

neuronal acetylcholine receptor subunit alpha-7

acetylcholine receptor alpha 7 neural	alpha7 nicotinic receptor
alpha7-nAChR

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02672	CHRNA7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS19768	Chrna7 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26265	Chrna7 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Chrna7	NCBI	NCBI:1139

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