Foxp2 - forkhead box P2 Gene

Mus musculus

Also known as CAG-16; D0Kist7; 2810043D05Rik

Gene ID: 114142 | Gene type: protein coding

About Foxp2

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in cerebellar Purkinje cell differentiation; gene expression; and vocalization behavior. Acts upstream of or within several processes, including animal organ development; positive regulation of cell population proliferation; and righting reflex. Is active in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; musculoskeletal system; and respiratory system. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; autism spectrum disorder (multiple); communication disorder (multiple); dyslexia; and major depressive disorder. Orthologous to human FOXP2 (forkhead box P2). [provided by Alliance of Genome Resources, Apr 2022]

Foxp2 Products(3)

mRNA	Protein	Name
NM_001286607.1	NP_001273536.1	forkhead box protein P2 isoform 2
NM_053242.4	NP_444472.2	forkhead box protein P2 isoform 1
NM_212435.1	NP_997600.1	forkhead box protein P2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	14701752	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	17428829	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	14701752	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	14701752	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	14701752	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	14701752	MGI
enables transcription coregulator binding	IPI IPI: Inferred from physical interaction	14701752	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within camera-type eye development	IMP IMP: Inferred from mutant phenotype	17619227	MGI
involved in cerebellar Purkinje cell differentiation	IMP IMP: Inferred from mutant phenotype	22133810	MGI
acts upstream of or within cerebellum development	IMP IMP: Inferred from mutant phenotype	15983371	MGI
acts upstream of or within embryo development	IGI IGI: Inferred from genetic interaction	17428829	MGI
acts upstream of epithelial cell proliferation involved in lung morphogenesis	IGI IGI: Inferred from genetic interaction	17428829	MGI
involved in gene expression	IMP IMP: Inferred from mutant phenotype	22133810	MGI
acts upstream of or within growth	IMP IMP: Inferred from mutant phenotype	17619227	MGI
acts upstream of or within lung alveolus development	IMP IMP: Inferred from mutant phenotype	17428829	MGI
acts upstream of or within lung development	IGI IGI: Inferred from genetic interaction	17428829	MGI
acts upstream of or within negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11358962	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	14701752	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	14701752	MGI
acts upstream of or within positive regulation of epithelial cell proliferation	IGI IGI: Inferred from genetic interaction	17428829	MGI
acts upstream of or within positive regulation of epithelial cell proliferation involved in lung morphogenesis	IGI IGI: Inferred from genetic interaction	17428829	MGI
acts upstream of or within positive regulation of mesenchymal cell proliferation	IGI IGI: Inferred from genetic interaction	17428829	MGI
acts upstream of or within post-embryonic development	IMP IMP: Inferred from mutant phenotype	17619227	MGI
acts upstream of or within righting reflex	IMP IMP: Inferred from mutant phenotype	17619227	MGI
acts upstream of or within skeletal muscle tissue development	IGI IGI: Inferred from genetic interaction	17428829	MGI
acts upstream of or within smooth muscle tissue development	IGI IGI: Inferred from genetic interaction	17428829	MGI
acts upstream of or within vocal learning	IMP IMP: Inferred from mutant phenotype	15983371	MGI
involved in vocalization behavior	IMP IMP: Inferred from mutant phenotype	22133810	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in nucleus	IDA IDA: Inferred from direct assay	22133810	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

forkhead box protein P2

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05074	FOXP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22516	Foxp2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29037	Foxp2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Foxp2	NCBI	NCBI:93986

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