2. Gene
  3. Asah2 - N-acylsphingosine amidohydrolase 2 Gene

Asah2 - N-acylsphingosine amidohydrolase 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 114104 | Gene type: protein coding

About Asah2

Summary

Enables dihydroceramidase activity and phytoceramidase activity. Involved in response to organic substance and sphingolipid metabolic process. Located in extracellular space; mitochondrion; and plasma membrane. Is integral component of plasma membrane. Colocalizes with membrane raft. Orthologous to several human genes including ASAH2B (N-acylsphingosine amidohydrolase 2B). [provided by Alliance of Genome Resources, Apr 2022]

Asah2 Products(1)

mRNA Protein Name
NM_053646.2 NP_446098.1 neutral ceramidase
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables N-acylsphingosine amidohydrolase activity IDA
IDA: Inferred from direct assay
10488143 RGD
Biological Process GO Annotation Evidence Reference Source
involved in ceramide biosynthetic process IDA
IDA: Inferred from direct assay
11278489 RGD
involved in ceramide catabolic process IDA
IDA: Inferred from direct assay
10488143 RGD
involved in sphingosine biosynthetic process IDA
IDA: Inferred from direct assay
10488143 RGD
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
12499379 RGD
located in membrane raft IDA
IDA: Inferred from direct assay
11328816 RGD
NOT located in mitochondrion IDA
IDA: Inferred from direct assay
15123644 RGD
located in mitochondrion IDA
IDA: Inferred from direct assay
21613224 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
11328816 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neutral ceramidase

N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2

NCDase

acylsphingosine deacylase 2

neutral/alkaline ceramidase

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01054 ASAH2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19409 Asah2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25901 Asah2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Asah2 NCBI NCBI:56624
Mus musculus Asah2 NCBI NCBI:54447